Evidence map›Paper›PMID 31659548›Full record

SynthesisHernia : the journal of hernias and abdominal wall surgery2020

Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis.

H Liu, S van Steensel, M Gielen, T Vercoulen, J Melenhorst, B Winkens, N D Bouvy

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

H LiuDepartment of General Surgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. h.liu@maastrichtuniversity.nl.ORCID 0000-0002-5277-584X
S van SteenselDepartment of General Surgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
M GielenFaculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
T VercoulenFaculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
J MelenhorstDepartment of General Surgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
B WinkensDepartment of Methodology and Statistics, CAPHRI, MUMC+, Maastricht, The Netherlands.
N D BouvyDepartment of General Surgery, Maastricht University Medical Centre, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.
Maastricht University Medical Centre · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLaparoscopic intraperitoneal onlay mesh in hernia repair can result in adhesions leading to intestinal obstruction and fistulation. The aim of this systematic review is to compare the effects of mesh coatings reducing the tissue-to-mesh adhesion in animal studies.

methodsPubmed and Embase were systematically searched. Animal experiments comparing intraperitoneally placed meshes with coatings were eligible for inclusion. Only studies with comparable follow-up, measurements, and species were included for data pooling and subsequent meta-analysis.

resultsA total of 131 articles met inclusion criteria, with four studies integrated into one comparison and five studies integrated into another comparison. Compared to uncoated polypropylene (PP) mesh, PP mesh coated with hyaluronic acid/carboxymethyl cellulose (HA/CMC) showed significantly reduced adhesion formation at follow-up of 4 weeks measured with adhesion score of extent (random effects model, mean difference,-  0.96, 95% CI - 1.32 to - 0.61, P < 0.001, I

conclusionHA/CMC coating reduces adhesion formation to PP mesh effectively at a follow-up of 4 weeks, while the anti-adhesive properties of PC mesh are inclusive comparing all study data.

Indexed as

AnimalsDisease Models, AnimalFemaleHerniorrhaphySurgical MeshTreatment OutcomeIPOMMeta-analysisSurgical meshSystematic reviewTissue adhesion

Identifiers

PMID31659548
PMCPMC7701080
OpenAlexW2981991592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.