ArticleWorld journal of surgery2020
Osteocalcin is an Independent Predictor for Hungry Bone Syndrome After Parathyroidectomy.
Article in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Predictive value of preoperative bone turnover markers for early postoperative severe hypocalcemia in patients with maintenance hemodialysis and secondary hyperparathyroidism.International urology and nephrology · 2026Article
- Predicting Hungry Bone Syndrome with Interpretable Machine Learning: A Single-Center Cohort of Dialysis Patients Undergoing Parathyroidectomy.Diagnostics (Basel, Switzerland) · 2026Article
- Severe Hypocalcemia in Hungry Bone Syndrome After Parathyroid Surgery: A Case Study and Review.The American journal of case reports · 2026Review
- Predictors of Hungry Bone Syndrome After Parathyroidectomy in Secondary Hyperparathyroidism: A Narrative Review of Bone Turnover Biomarkers and Risk Prediction Tools.Journal of clinical medicine · 2025Review
- Hungry Bone Syndrome After Parathyroidectomy for Secondary Hyperparathyroidism: Pathogenesis and Contemporary Clinical Considerations.Journal of clinical medicine · 2025Review
- Machine learning-based predictive model for hungry bone syndrome following parathyroidectomy in secondary hyperparathyroidism.Frontiers in endocrinology · 2025Article
- Abnormalities of serum magnesium levels in dialysis patients undergoing parathyroidectomy.Updates in surgery · 2024Article
- A nomogram prediction model for hungry bone syndrome in dialysis patients with secondary hyperparathyroidism after total parathyroidectomy.European journal of medical research · 2024Article
- Intensive Calcium Monitoring Following Parathyroidectomy: Prevention of Hungry Bone Syndrome in Children.Turkish archives of pediatrics · 2024Article
- Bilateral giant parathyroid adenoma and hungry bone syndrome: a case report.Journal of medical case reports · 2023Article
- Forestalling Hungry Bone Syndrome after Parathyroidectomy in Patients with Primary and Renal Hyperparathyroidism.Diagnostics (Basel, Switzerland) · 2023Review
- A reappraisal of risk factors for early hypocalcemia after parathyroidectomy in dialysis patients.Updates in surgery · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHungry bone syndrome is characterized by prolonged and severe hypocalcemia following parathyroidectomy. Previously, we reported that preoperative alkaline phosphatase is a major factor predicting prolonged hospital stay. Nonetheless, some patients with low alkaline phosphatase levels presented with hungry bone syndrome, suggesting that additional factors may play a role.
methodsFrom September 2010 to December 2017, consecutive dialysis patients who underwent parathyroidectomy for secondary hyperparathyroidism were analyzed. Length of hospital stay was used as a surrogate marker for postoperative bone hunger.
resultsA total of 260 patients were included in the study. The median postoperative hospital stay was 3 days, and 69 (27%) patients had a stay longer than 3 days. Multivariate logistic regression analysis revealed that alkaline phosphatase (odds ratio [OR] = 1.005), osteocalcin (OR = 1.001), and subtotal parathyroidectomy (OR = 0.061) were associated with prolonged hospital stay. Multivariate linear regression analysis indicated that age (β = - 0.170), alkaline phosphatase (β = 0.430), and osteocalcin (β = 0.166) were correlated with the length of stay. After surgery, the median osteocalcin level increased from 264 to 478 ng/mL (P < 0.001).
conclusionsAlkaline phosphatase is the main predictor of hungry bone syndrome after parathyroidectomy, and preoperative osteocalcin is an additional independent predictor. Patients with a high osteocalcin level may prone to have a higher demand for calcium supplementation.
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