ArticleNature biotechnology2019
Broad-spectrum resistance to bacterial blight in rice using genome editing.
Article in Nature biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 342 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
342 citing papers in PubMed, 1 synthesis or guideline pooled it, 816 citations in OpenAlex.
- Pooled it
- Reactivation of a loss-of-function SlGLK2 allele by frame-restoring genome editing in tomato.Plant cell reports · 2026Article
- Apoplast Engineering Unveiled: Multi-Target Strategies to Disarm Pathogens and Elevate Global Food Security.Plant, cell & environment · 2026Review
- Translating functional molecular knowledge into crop-breeding success.Nature reviews. Genetics · 2026Review
- Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- AI-designed OpenCRISPR-1 enables efficient targeted mutagenesis and prime editing in rice.aBIOTECH · 2026Article
- Two domesticated species of rice shaped the population structure of Xanthomonas oryzae pv. oryzae in Africa.PLoS pathogens · 2026Article
- Efficient CRISPR/Cas-SF01 genome editing tools with high editing efficiency in allotetraploid oilseed rape.Journal of integrative plant biology · 2026Article
- Climate Warming and Plant Disease: Mechanistic Insights Into Pathogenic Stress Resilience.Plant, cell & environment · 2026Review
- A grass-specific route to salicylic acid.Nature plants · 2026Article
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- A transcription factor TOE3 simultaneously promotes growth and antiviral immunity by disrupting ABA core module in tobacco.Science advances · 2026Article
- Nanotechnology-Enabled CRISPR Delivery: Emerging Opportunities in Agriculture and Forest Biotechnology.Plants (Basel, Switzerland) · 2026Review
- Genomic insights into the TAL effector diversity and SWEET gene targeting in Indian strains of Xanthomonas oryzae pv. oryzae.Archives of microbiology · 2026Article
- Control Targets in Plant-Pathogenic Bacteria: From Growth-Essential Processes to Anti-Virulence Strategies and Candidate Targets inPlants (Basel, Switzerland) · 2026Review
- Harnessing CRISPR-Cas technology to enhance rice resilience under abiotic and biotic stress.Journal of applied genetics · 2026Review
- A natural variation in rice susceptibility factor Rsf1 confers resistance to root-knot nematode.Nature communications · 2026Article
- Paradoxical Immune Phenotypes and Dual-State Immune Regulators in Plants: The GSL5 Case Study.International journal of molecular sciences · 2026Review
- Xanthomonas Type III Effector XopN Targets Scaffold Protein OsRACK1B to Suppress Rice Immunity.Molecular plant pathology · 2026Article
- NIT24 and NIT29-Dependent Auxin Biosynthesis Promotes Virulence and Auxin-SA Antagonism in Rice During Xanthomonas oryzae pv. oryzae Infection.The plant pathology journal · 2026Article
282 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial blight of rice is an important disease in Asia and Africa. The pathogen, Xanthomonas oryzae pv. oryzae (Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter genes SWEET11, SWEET13 and SWEET14, the expression of which is required for disease susceptibility. We used CRISPR-Cas9-mediated genome editing to introduce mutations in all three SWEET gene promoters. Editing was further informed by sequence analyses of TALe genes in 63 Xoo strains, which revealed multiple TALe variants for SWEET13 alleles. Mutations were also created in SWEET14, which is also targeted by two TALes from an African Xoo lineage. A total of five promoter mutations were simultaneously introduced into the rice line Kitaake and the elite mega varieties IR64 and Ciherang-Sub1. Paddy trials showed that genome-edited SWEET promoters endow rice lines with robust, broad-spectrum resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.