ArticleNature genetics2019
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.
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In one paragraph
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization.Arthritis & rheumatology (Hoboken, N.J.) · 2023Pooled it
- FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells.Circulation research · 2023Pooled it
- Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape.Journal of the American Heart Association · 2020Pooled it
- Comprehensive mass spectrometry screening-derived atlas of HDAC inhibitors reveals histone-specific acetylation changes.Cell reports · 2026Article
- YAK577 Attenuates Vascular Calcification by Targeting an MMP14-NOX2/ROS Axis in VSMCs and a Vitamin DAntioxidants (Basel, Switzerland) · 2026Article
- Post-Stroke Depression Is Associated With Shared Neurodevelopmental Risk and Circuit Disruption.Brain and behavior · 2026Article
- Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice.Nature biomedical engineering · 2026Article
- Ketogenic diet and β-hydroxybutyrate inhibit HDAC1 to preserve vascular smooth muscle cell function in thoracic aortic aneurysm.Journal of advanced research · 2026Article
- A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease.Biomolecules · 2026Review
- HDAC inhibitors in cancer therapy: sensitization mechanisms, combination strategies, and translational challenges.Frontiers in cell and developmental biology · 2026Review
- HDAC6 deficiency exacerbates atherosclerosis via STAT3-K685 acetylation-mediated CD36/SR-A upregulation in macrophages.Cell death & disease · 2025Article
- The multifactorial role of HDAC9 at the maternal-fetal interface in the pathogenesis of preeclampsia.Clinical science (London, England : 1979) · 2025Review
- Focal Adhesion Kinase Promotes Calcification of Vascular Smooth Muscle Cells via Regulation of Histone Deacetylase 4 and 5.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Medial arterial calcification in ageing and disease: current evidence and knowledge gaps.European heart journal · 2025Review
- Role of vascular smooth muscle phenotypic transformation induced by histone modifications in the development of abdominal aortic aneurysms.Clinical epigenetics · 2025Review
- Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Class IIa HDACs Are Important Signal Transducers with Unclear Enzymatic Activities.Biomolecules · 2025Review
- Vascular Smooth Muscle Cells: A Therapeutic Target in Atherosclerosis.Reviews in cardiovascular medicine · 2025Review
- Review
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32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
50 authors at 20 institutions in 6 countries.
Rajeev MalhotraDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. rmalhotra@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-0120-4630
Andreas C MauerDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Christian L Lino CardenasDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5491-4375
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Jie YaoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiaoling ZhangNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Florian WundererDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Albert V SmithIcelandic Heart Association, Kópavogur, Iceland.
Quenna WongDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sonali PechlivanisInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Shih-Jen HwangNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Judy WangDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Lingyi LuWake Forest School of Medicine, Winston-Salem, NC, USA.
Christopher J NicholsonDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Georgia SheltonDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mary D BuswellDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hanna J BarnesDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Haakon H SigurslidDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Charles SlocumDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Caitlin O' RourkeDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
David K RheeDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Aranya BagchiHarvard Medical School, Boston, MA, USA.
Sagar U NigwekarHarvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6750-0072
Emmanuel S BuysHarvard Medical School, Boston, MA, USA.
Catherine Y CampbellMid-Atlantic Permanente Medical Group, Rockville, MD, USA.
Tamara HarrisNational Institute on Aging, Bethesda, MD, USA.
Matthew BudoffDivision of Cardiology, Department of Medicine and Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
Michael H CriquiDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Andrew D JohnsonNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Ci SongNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Stephanie DebetteInserm U1219, University of Bordeaux, Bordeaux, France.
Udo HoffmannHarvard Medical School, Boston, MA, USA.
Hagen KälschDepartment of Cardiology, Alfried Krupp Hospital, Essen, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Sigurdur SigurdssonIcelandic Heart Association, Kópavogur, Iceland.
Barry I FreedmanWake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0003-0275-5530
Donald W BowdenWake Forest School of Medicine, Winston-Salem, NC, USA.
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Susanne MoebusInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Raimund ErbelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany.
Mary F FeitosaDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0933-2410
Vilmundur GudnasonIcelandic Heart Association, Kópavogur, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
George ThanassoulisNational Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA.
Warren M ZapolHarvard Medical School, Boston, MA, USA.
Mark E LindsayDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Donald B Bloch *Harvard Medical School, Boston, MA, USA.
Wendy S Post *Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Christopher J O'Donnell *Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. Christopher.ODonnell@va.gov.ORCID http://orcid.org/0000-0002-2667-8624
Harvard University · USMassachusetts General Hospital · USInstitut für Medizinische Informatik, Biometrie und Epidemiologie · DEThe Lundquist Institute · USWake Forest University · USNational Heart Lung and Blood Institute · USBoston University · USColorado Permanente Medical Group · USGoethe University Frankfurt · DEIcelandic Heart Association · ISJohns Hopkins University · USMcGill University Health Centre · CANational Institute on Aging · USUnited States Department of Veterans Affairs · USUniversité de Bordeaux · FRUniversity of Bonn · DEUniversity of California San Diego · USUniversity of Iceland · ISUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MREPRIEVE - DCCU01HL123339 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LU, MICHAEL TSE-YIN, RIBAUDO, HEATHER JANE · 2014 to 2019
$6.0MCardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9MGenetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6MSubclinical CVD in African American Type 2 DiabeticsR01DK071891 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2007 to 2016
$4.5MModulation of Hepcidin-Ferroportin Signaling using Small MoleculesR01DK082971 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BLOCH, DONALD B, PETERSON, RANDALL T · 2009 to 2018
$4.5MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS M01 RR007122NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS K08 HL111210NHLBI NIH HHS K24 HL113128NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL067348NHLBI NIH HHS R01 HL071739NHLBI NIH HHS R01 HL072403NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL109711NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL130113NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R21 HL140385NHLBI NIH HHS T32 HL076136NHLBI NIH HHS U01 HL123339NIA NIH HHS N01 AG012100NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK071891NIDDK NIH HHS R01 DK082971NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK117445NIMHD NIH HHS R01 MD012765NINDS NIH HHS R01 NS125353
Abstract
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.0 × 10
Indexed as
Genetic Predisposition to DiseaseMuscle ContractionAgedAnimalsAortaAtherosclerosisCohort StudiesFemaleGenome-Wide Association StudyGTPase-Activating ProteinsHistone DeacetylasesHumansMaleMiceMice, Inbred C57BLMice, KnockoutGTPase-Activating ProteinsHDAC9 protein, humanHdac9 protein, mouseHistone DeacetylasesRAP1GAP protein, humanRepressor Proteins
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