ArticleNature chemistry2019
Tailored silyl ether monomers enable backbone-degradable polynorbornene-based linear, bottlebrush and star copolymers through ROMP.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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Who cites it
49 citing papers in PubMed, 229 citations in OpenAlex.
- Dynamic Covalent Lewis Pair Grafting Enables Spontaneous Linear-to-Bottlebrush Polymer Assembly and Adaptive Elastomers.ACS macro letters · 2026Article
- Bottlebrush Polyolefin Sulfones as Triggerable and Degradable Pressure-Sensitive Adhesives.Angewandte Chemie (International ed. in English) · 2026Article
- Hydrolytically Degradable Polyethylene Glycol Bottlebrush Polymers Address the Stability-Clearance Trade-Off for Drug Delivery.Polymer science & technology (Washington, D.C.) · 2026Article
- DFT study of selective hydrogenation of non-conjugated dienes on a Pd surface: the case of 2,5-norbornadiene.Journal of molecular modeling · 2026Article
- Orchestrating photoswitch thermal backconversion using hydrogen bonds to reshape energy landscapes.Nature communications · 2026Article
- Recyclable Graft Polymer Enabled by RAFT Step-Growth Polymerization and Deconstruction.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Antibody-bottlebrush prodrug conjugates for targeted cancer therapy.Nature biotechnology · 2026Article
- Recyclable thermoplastic silicone elastomers from non-carbon heteroatomic polymer backbones.Nature communications · 2026Article
- Design, Synthesis and ROMP of NovelMaterials (Basel, Switzerland) · 2026Article
- Entropy-Driven Design of Depolymerizable Polyolefins from Strained Bridged Bicyclic Monomers.Journal of the American Chemical Society · 2026Article
- C6-ROMP Enabled by Structure-Guided Monomer Design for Chemically Recyclable Polymers.Nature communications · 2026Article
- Conformational preorganization of neighbouring groups modulates and expedites polymer self-deconstruction.Nature chemistry · 2026Article
- Advanced Macromolecular Architectures via Inorganic Polymers.Macromolecular rapid communications · 2026Review
- Ring-Opening Metathesis Copolymerization of [7]Helicene-Fused Oxanorbornene and Norbornene: Polymerization Control and Physical Properties.Chemistry, an Asian journal · 2026Article
- Conformation-driven reversibility control in ring-opening metathesis polymerization of non-bicyclic cyclooctenes.Nature communications · 2025Article
- RAFT Step-Growth Polymerization via 'Grafting Through'.ACS polymers Au · 2025Article
- Advances in sustainable polyolefins: synthesis, chemical transformation and recycling.National science review · 2025Review
- Impact of Stereocontrolled Polynorbornene Synthesis on Degradation Rate.Macromolecules · 2025Article
- Cleavable Additives for Deconstructable, Recyclable Polyurethane Thermosets.ACS central science · 2025Article
- Entropy Drives the Predictive Discovery of an Optimal Cleavable Comonomer for ROMP.ACS central science · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ring-opening metathesis polymerization of norbornene-based (macro)monomers is a powerful approach for the synthesis of macromolecules with diverse compositions and complex architectures. Nevertheless, a fundamental limitation of polymers prepared by this strategy is their lack of facile degradability, limiting their utility in a range of applications. Here we describe a class of readily available bifunctional silyl ether-based cyclic olefins that copolymerize efficiently with norbornene-based (macro)monomers to provide copolymers with backbone degradability under mildly acidic aqueous conditions and degradation rates that can be tuned over several orders of magnitude, depending on the silyl ether substituents. These monomers can be used to manipulate the in vivo biodistribution and clearance rate of polyethylene glycol-based bottlebrush polymers, as well as to synthesize linear, bottlebrush and brush-arm star copolymers with degradable segments. We expect that this work will enable preparation of degradable polymers by ROMP for biomedical applications, responsive self-assembly and improved sustainability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.