Evidence map›Paper›PMID 31659306›Full record

ArticleNature biomedical engineering2019

Patient-specific reconstruction of volumetric computed tomography images from a single projection view via deep learning.

Liyue Shen, Wei Zhao, Lei Xing

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. AI in Proton Therapy Treatment Planning: A Narrative Review.International journal of particle therapy · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Real-Time Dose-Guided Radiation Therapy.International journal of radiation oncology, biology, physics · 2025
    Review
  20. Article

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Liyue ShenDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Wei ZhaoDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6182-4746
Lei XingDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. lei@stanford.edu.ORCID http://orcid.org/0000-0003-2536-5359

Funding

Dual Modality X-ray Luminescence CT for in vivo Cancer ImagingR01CA227713 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2019 to 2023
$2.9M
Radioluminescence dosimetry solution for precision radiation therapyR01CA223667 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2018 to 2022
$2.4M
DASSIM-RT and Compressed Sensing-Based Inverse PlanningR01CA176553 · NCI · STANFORD UNIVERSITY · PI XING, LEI · 2014 to 2018
$2.4M
Computational Tools for Next Generation Volumetric Cone Beam Computed TomographyR01EB016777 · NIBIB · STANFORD UNIVERSITY · PI XING, LEI · 2013 to 2016
$2.1M
NCI NIH HHS R01 CA176553NCI NIH HHS R01 CA223667NCI NIH HHS R01 CA227713NIBIB NIH HHS R01 EB016777
6 · The paper itself

Abstract

Tomographic imaging using penetrating waves generates cross-sectional views of the internal anatomy of a living subject. For artefact-free volumetric imaging, projection views from a large number of angular positions are required. Here we show that a deep-learning model trained to map projection radiographs of a patient to the corresponding 3D anatomy can subsequently generate volumetric tomographic X-ray images of the patient from a single projection view. We demonstrate the feasibility of the approach with upper-abdomen, lung, and head-and-neck computed tomography scans from three patients. Volumetric reconstruction via deep learning could be useful in image-guided interventional procedures such as radiation therapy and needle biopsy, and might help simplify the hardware of tomographic imaging systems.

Indexed as

Deep LearningAbdomenBiopsy, NeedleCone-Beam Computed TomographyHeadHumansImaging, Three-DimensionalLungNeckRadiotherapyRadiotherapy Planning, Computer-Assisted

Identifiers

PMID31659306
PMCPMC6858583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.