Evidence map›Paper›PMID 31659300›Full record

ArticleMucosal immunology2020

Generation of protective pneumococcal-specific nasal resident memory CD4

Joanne M O'Hara, Naresh S Redhu, Elaine Cheung, Nahid G Robertson, Izabel Patik, Shorouk El Sayed, Claudette M Thompson, Muriel Herd, Katherine B Lucas, Evan Conaway and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Lung-resident lymphocytes and their roles in respiratory infections and chronic respiratory diseases.Chinese medical journal pulmonary and critical care medicine · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. CD4Nature immunology · 2023
    Review
  14. Article
  15. Article
  16. Expansion of cytotoxic tissue-resident CD8Nature communications · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Immunization with HMW1 and HMW2 adhesins protects against colonization by heterologous strains of nontypeableProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Joanne M O'HaraDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Naresh S RedhuHarvard Medical School, Boston, MA, USA.
Elaine CheungDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Nahid G RobertsonDepartment of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA.
Izabel PatikDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Shorouk El SayedDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Claudette M ThompsonDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Muriel HerdDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Katherine B LucasDivision of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Evan ConawayDepartment of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Cynthia C MortonHarvard Medical School, Boston, MA, USA.
Donna L FarberColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA.
Richard Malley *Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. richard.malley@childrens.harvard.edu.
Bruce H Horwitz *Harvard Medical School, Boston, MA, USA. bhorwitz@rics.bwh.harvard.edu.
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · USColorado State University · USColumbia University Irving Medical Center · US

Funding

Development of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9M
Development of lung T cell responses in infant respiratory immunityR01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2012 to 2016
$2.6M
Enhancing neonatal immunity to Streptococcus pneumoniaeR01AI100114 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MALLEY, RICHARD · 2012 to 2016
$2.1M
NIAID NIH HHS R01 AI100114NIAID NIH HHS R01 AI100119NIAID NIH HHS U01 AI100119
6 · The paper itself

Abstract

The generation of tissue-resident memory T cells (T

Indexed as

AnimalsCD4-Positive T-LymphocytesCells, CulturedDisease ResistanceHumansImmunologic MemoryInterleukin-17Lymphocyte ActivationMiceMice, Inbred C57BLNosePneumococcal InfectionsStreptococcal VaccinesStreptococcus pneumoniaeVaccinationInterleukin-17Streptococcal Vaccines

Identifiers

PMID31659300
PMCPMC6917870
OpenAlexW2982016609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.