Evidence map›Paper›PMID 31659287›Full record

ArticleEye (London, England)2020

Real-world management and long-term outcomes of diabetic macular oedema with good visual acuity.

Kieu-Yen Luu, Mutaal M Akhter, Blythe P Durbin-Johnson, Ala Moshiri, Steven Tran, Lawrence S Morse, Susanna S Park, Glenn Yiu

Abstract read
In one paragraph

Article in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kieu-Yen Luu *Department of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0001-8763-3406
Mutaal M Akhter *Department of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.
Blythe P Durbin-JohnsonDepartment of Public Health Sciences, University of California, Davis, Sacramento, CA, USA.
Ala MoshiriDepartment of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.
Steven TranRosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Lawrence S MorseDepartment of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.
Susanna S ParkDepartment of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0001-5911-6671
Glenn YiuDepartment of Ophthalmology & Vision Sciences, University of California, Davis, Sacramento, CA, USA. gyiu@ucdavis.edu.ORCID http://orcid.org/0000-0003-3061-3310

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Novel Model Systems for the Study of Cone Disorders and Other Heritable Retinal DiseasesU24EY029904 · NEI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI, ROGERS, JEFFREY A. · 2018 to 2023
$7.7M
The Phase I/II Randomized, Prospective, Double-blinded, Sham-controlled Cross-over Study of Intravitreal Autologous Bone Marrow CD34+ Stem Cell Therapy for Retinal Vein OcclusionUG1EY026876 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PARK, SUSANNA S · 2018 to 2022
$2.6M
The Role of ARAP1 in Retinal Photoreceptor HomeostasisK08EY027463 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MOSHIRI, ALA · 2017 to 2021
$1.0M
A nanoparticle platform for targeted delivery of therapeutic agents to retinal pigment epithelial or choroidal endothelial cellsK08EY026101 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YIU, GLENN · 2016 to 2020
$1.0M
Optogenetic Control of Oxidative Stress as a Model of Geographic AtrophyR21EY031108 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YIU, GLENN · 2019 to 2019
$312k
NCATS NIH HHS UL1 TR001860NEI NIH HHS K08 EY026101NEI NIH HHS K08 EY027463NEI NIH HHS R21 EY031108NEI NIH HHS U24 EY029904NEI NIH HHS UG1 EY026876
6 · The paper itself

Abstract

purposeTo evaluate the management and long-term outcomes of patients with diabetic macular oedema (DMO) and good initial visual acuity in real-world settings.

methodsWe reviewed 122 eyes of 100 patients with treatment-naive DMO and initial best-corrected visual acuity (BCVA) of 20/25 or better. We assessed clinical characteristics, logMAR BCVA, central subfield thickness (CST), cumulative intravitreal injections and laser treatments at yearly intervals, and characteristics at time of initial treatment. Linear mixed effects models were used to identify predictors of visual outcomes.

resultsAt presentation, mean BCVA was 0.057 ± 0.048 logMAR (Snellen 20/23) and mean CST was 288 ± 57 μm. After a median follow-up of 3 years, 51% of eyes underwent treatment. More eyes underwent intravitreal injection as initial treatment (54%), but lasers were initiated at an earlier time and at better BCVA. Final BCVA was associated with better BCVA (P < 0.001) and earlier timing (P = 0.017) at initial treatment, but not CST at first treatment (P = 0.634) or cumulative number of injections or lasers (P = 0.441-0.606).

conclusionDMO with good initial visual acuity should be monitored closely, as delay in treatment initiation is associated with worse visual outcomes. BCVA at time of initial treatment is the strongest determinant of final visual acuity.

Indexed as

Diabetes MellitusDiabetic RetinopathyMacular EdemaAngiogenesis InhibitorsBevacizumabHumansIntravitreal InjectionsRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVisual AcuityAngiogenesis InhibitorsBevacizumab

Identifiers

PMID31659287
PMCPMC7253473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.