ArticleMolecular psychiatry2021
Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism.
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- Gene-environment correlations and causal effects of childhood maltreatment on physical and mental health: a genetically informed approach.The lancet. Psychiatry · 2021Pooled it
- Common genetic variants are associated with increased likelihood of latent co-occurring neurodevelopmental and mental health factors among autistic individuals.Molecular psychiatry · 2026Article
- Unraveling the Genetic Basis of Self-Harm Phenotypes: New Perspectives on Its Links to Depression and Chronic Pain.Biological psychiatry global open science · 2026Article
- Exploring Patterns of Self-Harm in Autistic Adults Using the Card Sort Task for Self-Harm.Autism : the international journal of research and practice · 2026Article
- Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Associations of smoking and alcohol consumption with suicidality in major depressive disorder: a cross-sectional analysis of UK Biobank.BMC psychiatry · 2026Article
- Neurodiversity-Affirming Applied Behavior Analysis.Behavior analysis in practice · 2026Article
- Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Psychiatric genetics · 2026Article
- Nomogram for suicidal ideation and non-suicidal self-injury risk assessment in Dehong District nursing staff: a cross-sectional study.BMJ open · 2025Article
- Systematic Review and Meta-Analysis: Phenotypic Correlates of the Autism Polygenic Score.JAACAP open · 2025Article
- Self-harm and suicidality experiences of autistic and non-autistic adults in midlife and old age.Molecular autism · 2025Article
- Advancing Research on Suicide and Mental Health in Autistic Adults Through a Research Domain Criteria (RDoC)-Inspired Framework.Autism in adulthood · 2025Article
- Autistic traits in childhood and post-traumatic stress disorder as young adults: a cohort study.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- "A combination of everything": a mixed-methods approach to the factors which autistic people consider important in suicidality.Autism in adulthood · 2025Article
- The roles of adverse childhood experiences and genetic liability in risk for suicidal thoughts and behaviors: A factor analytic approach.Journal of affective disorders · 2025Article
- Lifetime stressor exposure is related to suicidality in autistic adults: A multinational study.Autism : the international journal of research and practice · 2025Article
- FKBP51 in glutamatergic forebrain neurons promotes early life stress inoculation in female mice.Nature communications · 2025Article
- Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour.International journal of molecular sciences · 2025Review
- Research Review: Why do prospective and retrospective measures of maltreatment differ? A narrative review.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autism is associated with childhood trauma using polygenic scores (PGS) and genetic correlations in the UK Biobank (105,222 < N < 105,638), and tested potential mediators and moderators of the association between autism, childhood trauma and SSBI. Autism PGS were significantly associated with childhood trauma (max R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.