ArticleScientific reports2019
Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A descriptive analysis of Streptococcus suis-associated disease in Irish pigs from 2010 to 2024: serotypes, pathology, and antimicrobial resistance.Irish veterinary journal · 2026Article
- Serotype independent protection induced by a vaccine based on the IgM protease of Streptococcus suis and proposal for a new immunity-based classification system.Porcine health management · 2024Article
- Translocation across a human enteroid monolayer by zoonoticiScience · 2024Article
- Comparative analysis of the interactions of different Streptococcus suis strains with monocytes, granulocytes and the complement system in porcine blood.Veterinary research · 2024Article
- Epidemiology and genetic diversity of Streptococcus suis in smallhold swine farms in the Philippines.Scientific reports · 2023Article
- A critical review on experimental Streptococcus suis infection in pigs with a focus on clinical monitoring and refinement strategies.BMC veterinary research · 2023Review
- Evaluation of pathotype marker genes in Streptococcus suis isolated from human and clinically healthy swine in Thailand.BMC microbiology · 2023Article
- A new S. suis serotype 3 infection model in pigs: lack of effect of buprenorphine treatment to reduce distress.BMC veterinary research · 2022Article
- New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.Emerging infectious diseases · 2022Article
- Article
- Update onPathogens (Basel, Switzerland) · 2020Article
- A critical review speculating on the protective efficacies of autogenousPorcine health management · 2020Review
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9 authors.
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Abstract
Streptococcus suis is a porcine pathogen, causing severe invasive infections. S. suis serotype 9 is increasingly causing disease in Dutch and Chinese pig herds, but it is unknown whether all serotype 9 isolates are equally virulent and markers that can identify virulent strains are not available. Therefore, discrimination between virulent isolates and carriage isolates typically not associated with disease, is currently not possible. We collected tonsillar S. suis isolates from 6 herds not previously diagnosed with S. suis infections, and clinical S. suis isolates of previously diseased pigs. We confirmed the virulence of a virulent type strain and one representative clinical isolate, and the lack of virulence of two carriage isolates, in a pig infection model. Phylogenetic analysis of whole genome sequences of 124 isolates resulted in 10 groups, of which two were almost uniquely populated by clinical isolates. The population structure of S. suis serotype 9 appears highly diverse. However, analysis of the capsule loci sequences showed variation in a single region which fully correlated with a virulent genotype. Transmission electron microscopy suggested differences in capsule thickness between carriage and clinical genotypes. In conclusion, we found that that the S. suis serotype 9 population in the Netherlands is diverse. A distinct virulence-associated lineage was identified and could be discriminated based on the capsule locus sequence. Whilst the difference in virulence cannot be directly attributed to the DNA sequence, the correlation of capsule locus sequence with virulence could be used in the development of diagnostic tests to identify potential virulent S. suis serotype 9 in pigs.
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