Evidence map›Paper›PMID 31659117›Full record

ArticleThe Journal of biological chemistry2020

Nucleobase mutants of a bacterial preQ

Debapratim Dutta, Joseph E Wedekind

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. RNA Triple Helices: From Structures and Mechanisms to Therapeutic Targets.International journal of biological sciences · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Full-Length NADBiochemistry · 2023
    Article
  6. Structure and function analysis of a type III preQThe Journal of biological chemistry · 2023
    Article
  7. Article
  8. Article
  9. A chemical probe based on the PreQNature communications · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Conscious uncoupling of riboswitch functions.The Journal of biological chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Debapratim DuttaDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642.
Joseph E WedekindDepartment of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642. Electronic address: joseph.wedekind@rochester.edu.
University of Rochester · US

Funding

Mechanisms of Action On Non-Coding RNA MoleculesR01GM063162 · NIGMS · UNIVERSITY OF ROCHESTER · PI WEDEKIND, JOSEPH E · 2001 to 2024
$6.8M
NIGMS NIH HHS R01 GM063162
6 · The paper itself

Abstract

Riboswitches are a class of nonprotein-coding RNAs that directly sense cellular metabolites to regulate gene expression. They are model systems for analyzing RNA-ligand interactions and are established targets for antibacterial agents. Many studies have analyzed the ligand-binding properties of riboswitches, but this work has outpaced our understanding of the underlying chemical pathways that govern riboswitch-controlled gene expression. To address this knowledge gap, we prepared 15 mutants of the preQ

Indexed as

Gene Expression Regulation, BacterialMutationBase SequenceBinding SitesPyrimidinonesPyrrolesRiboswitchRNA, Bacterial7-(aminomethyl)-7-deazaguaninePyrimidinonesPyrrolesRiboswitchRNA, BacterialA-minor motifbacteriabase triplesgene expressiongene regulationisothermal titration calorimetry (ITC)mutantpreQ1 riboswitchpseudoknotriboswitchRNA structureShine-Dalgarno sequence

Identifiers

PMID31659117
PMCPMC7049981
OpenAlexW2982401712

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.