Trial reportCancer genomics & proteomics
Genetic Characterization of Myoid Hamartoma of the Breast.
Trial report in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Uncommon but Important: Tertiary Center Experience with Rare Cases of Breast Hamartoma.Life (Basel, Switzerland) · 2025Article
- The diagnosis and treatment of 56 cases of breast hamartoma: a single-center analysis and a review of the literature.Frontiers in medicine · 2024Article
- Clinical management of myoid hamartomas of the breast: A case report and literature review.Heliyon · 2022Article
- Case Report: A novelFrontiers in oncology · 2022Article
- Neoplasia-associated Chromosome Translocations Resulting in Gene Truncation.Cancer genomics & proteomicsReview
- Article
- Fusion of the High-mobility Group AT-Hook 2 (In vivo (Athens, Greece)Article
- Presence of a t(12;18)(q14;q21) Chromosome Translocation and Fusion of the Genes for High-mobility Group AT-Hook 2 (Cancer genomics & proteomicsArticle
- Chromosomal Translocation t(5;12)(p13;q14) Leading to Fusion of High-mobility Group AT-hook 2 Gene With Intergenic Sequences From Chromosome Sub-Band 5p13.2 in Benign Myoid Neoplasms of the Breast: A Second Case.Cancer genomics & proteomicsArticle
- Fusion of theIn vivo (Athens, Greece)Article
- Fusion of the Lumican (Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimMyoid hamartoma of the breast is a very rare benign lesion of which only a few cases have been reported. The pathogenesis is unknown and nothing is known about its genetic constitution. We report here the genetic characterization of a myoid hamartoma of the breast. MATERIALS AND
methodsCytogenetic, fluorescence in situ hybridization (FISH), RNA sequencing, reverse transcription polymerase chain reaction (RT-PCR), and Sanger sequencing analyses were performed on a myoid hamartoma of the breast.
resultsG-Banding analysis of short-term cultured tumor cells yielded the karyotype 46,XX,t(5;12)(p13;q14)[6]/46,XX[4]. FISH showed rearrangement of the high mobility group AT-hook 2 (HMGA2) gene. RNA sequencing detected fusion of HMGA2 (12q14) with a sequence from 5p13. RT-PCR together with Sanger sequencing verified the HMGA2-fusion transcript.
conclusionMyoid hamartoma of the breast may be pathogenetically related to benign connective tissue tumors with HMGA2 rearrangements, such as pulmonary hamartomas, lipomas, myolipomas, and leiomyomas.
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