ArticleProceedings of the National Academy of Sciences of the United States of America2019
Plant defense resistance in natural enemies of a specialist insect herbivore.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 71 citations in OpenAlex.
- Detoxification of conifer antimicrobial defenses promotes entomopathogenic fungus infection of bark beetles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic architecture of resistance to plant secondary metabolites in Photorhabdus entomopathogenic bacteria.BMC genomics · 2025Article
- Component specific responses of the microbiomes to common chemical stressors in the human food chain.Environmental microbiome · 2025Article
- Description of Heterorhabditis americana n. sp. (Rhabditida, Heterorhabditidae), a new entomopathogenic nematode species isolated in North America.Parasites & vectors · 2025Article
- Entomopathogenic Nematode Species Vary in Their Behavior and Virulence in Response to Cardiac Glycosides Within and Around Insect Hosts.Journal of chemical ecology · 2025Article
- Alanine metabolism mediates energy allocation of the brown planthopper to adapt to resistant rice.Journal of advanced research · 2025Article
- Photorhabdus viridis sp. nov. Isolated from Heterorhabditis zealandica Entomopathogenic Nematodes.Current microbiology · 2024Article
- Brandt's vole (Ecology and evolution · 2024Article
- Photorhabdus africana sp. nov. isolated from Heterorhabditis entomopathogenic nematodes.Current microbiology · 2024Article
- Biochemical Responses inPlants (Basel, Switzerland) · 2024Article
- Root-exuded specialized metabolites reduce arsenic toxicity in maize.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Genetic Variation, DIMBOA Accumulation, and Candidate Gene Identification in Maize Multiple Insect-Resistance.International journal of molecular sciences · 2023Article
- Sequestration of cucurbitacins from cucumber plants byJournal of pest science · 2023Article
- Functional diversity and metabolic engineering of plant-specialized metabolites.Life metabolism · 2022Review
- Functional Ecology of External Secretory Structures inPlants (Basel, Switzerland) · 2022Article
- Review
- Evolutionary Ecology of Plant-Arthropod Interactions in Light of the "Omics" Sciences: A Broad Guide.Frontiers in plant science · 2022Review
- Metabolization and sequestration of plant specialized metabolites in insect herbivores: Current and emerging approaches.Frontiers in physiology · 2022Review
- Novel trifluoromethylpyridine piperazine derivatives as potential plant activators.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants defend themselves against herbivores through the production of toxic and deterrent metabolites. Adapted herbivores can tolerate and sometimes sequester these metabolites, allowing them to feed on defended plants and become toxic to their own enemies. Can herbivore natural enemies overcome sequestered plant defense metabolites to prey on adapted herbivores? To address this question, we studied how entomopathogenic nematodes cope with benzoxazinoid defense metabolites that are produced by grasses and sequestered by a specialist maize herbivore, the western corn rootworm. We find that nematodes from US maize fields in regions in which the western corn rootworm was present over the last 50 y are behaviorally and metabolically resistant to sequestered benzoxazinoids and more infective toward the western corn rootworm than nematodes from other parts of the world. Exposure of a benzoxazinoid-susceptible nematode strain to the western corn rootworm for 5 generations results in higher behavioral and metabolic resistance and benzoxazinoid-dependent infectivity toward the western corn rootworm. Thus, herbivores that are exposed to a plant defense sequestering herbivore can evolve both behavioral and metabolic resistance to plant defense metabolites, and these traits are associated with higher infectivity toward a defense sequestering herbivore. We conclude that plant defense metabolites that are transferred through adapted herbivores may result in the evolution of resistance in herbivore natural enemies. Our study also identifies plant defense resistance as a potential target for the improvement of biological control agents.
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