Evidence map›Paper›PMID 31659045›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Scaffold subunits support associated subunit assembly in the

Long Gui, Kangkang Song, Douglas Tritschler, Raqual Bower, Si Yan, Aguang Dai, Katherine Augspurger, Jason Sakizadeh, Magdalena Grzemska, Thomas Ni and 2 more

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
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  5. Axonemal dynein contributions to flagellar beat types and waveforms.bioRxiv : the preprint server for biology · 2025
    Article
  6. Mouse radial spoke 3 is a metabolic and regulatory hub in cilia.Nature structural & molecular biology · 2025
    Article
  7. Review
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  15. Effects ofHuman reproduction open · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Long GuiDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kangkang SongDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Douglas TritschlerDepartment of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455.
Raqual BowerDepartment of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455.
Si YanDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Aguang DaiDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Katherine AugspurgerDepartment of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455.
Jason SakizadehDepartment of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455.
Magdalena GrzemskaDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5306-3553
Thomas NiDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Mary E PorterDepartment of Genetics, Cell Biology, and Development, University of Minnesota Medical School, Minneapolis, MN 55455 porte001@umn.edu daniela.nicastro@utsouthwestern.edu.
Daniela NicastroDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; porte001@umn.edu daniela.nicastro@utsouthwestern.edu.ORCID 0000-0002-0122-7173
The University of Texas Southwestern Medical Center · USUniversity of Minnesota Medical Center · US

Funding

Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Assembly, Targeting, And Regulation Of Dynein MotorsR01GM055667 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PORTER, MARY E. · 1997 to 2023
$5.4M
NIGMS NIH HHS R01 GM055667NIGMS NIH HHS R01 GM083122
6 · The paper itself

Abstract

The nexin-dynein regulatory complex (N-DRC) in motile cilia and flagella functions as a linker between neighboring doublet microtubules, acts to stabilize the axonemal core structure, and serves as a central hub for the regulation of ciliary motility. Although the N-DRC has been studied extensively using genetic, biochemical, and structural approaches, the precise arrangement of the 11 (or more) N-DRC subunits remains unknown. Here, using cryo-electron tomography, we have compared the structure of

Indexed as

ChlamydomonasDyneinsFlagellaMicrotubule-Associated ProteinsProtein Structure, QuaternaryDyneinsMicrotubule-Associated Proteinsmicrotubule nexinaxonemeciliacryo-electron tomographyflagellaN-DRC

Identifiers

PMID31659045
PMCPMC6859327
OpenAlexW2982503296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.