Evidence map›Paper›PMID 31659023›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Natural human genetic variation determines basal and inducible expression of

Kiara K Benson, Wenxiang Hu, Angela H Weller, Alexis H Bennett, Eric R Chen, Sumeet A Khetarpal, Satoshi Yoshino, William P Bone, Lin Wang, Joshua D Rabinowitz and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Hypermethylation ofJournal of the American Heart Association · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Disparities in COVID-19 severities and casualties across ethnic groups around the globe and patterns of ACE2 and PIR variants.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kiara K BensonDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Wenxiang HuDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Angela H WellerDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Alexis H BennettDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Eric R ChenDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Sumeet A KhetarpalDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Satoshi YoshinoDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
William P BoneDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lin WangDepartment of Chemistry, Princeton University, Princeton, NJ 08544.ORCID 0000-0002-9370-6891
Joshua D RabinowitzDepartment of Chemistry, Princeton University, Princeton, NJ 08544.
Benjamin F VoightDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Raymond E SoccioDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; soccio@pennmedicine.upenn.edu.ORCID 0000-0001-8863-1381
University of Pennsylvania · USPrinceton University · USTranslational Therapeutics (United States) · US

Funding

VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DOUGLAS J EPSTEIN · 1986 to 2026
$48.3M
Nuclear Receptors in Metabolic TissuesR01DK049780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LAZAR, MITCHELL A. · 1995 to 2025
$10.8M
Diabetes, Endocrine, and MetabolismT32DK007314 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DORIS A STOFFERS, Patrick Seale · 1986 to 2026
$9.0M
Algorithms to identify non-coding mutational burden and disease-relevant pathwaysR01DK101478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI VOIGHT, BENJAMIN FRANKLIN · 2014 to 2018
$2.9M
Translating human PPARy binding regions to gene regulation and metabolic diseaseK08DK094968 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SOCCIO, RAYMOND EDWARD · 2012 to 2016
$775k
Algorithms to identify non-coding mutational burden and disease-relevant pathwaysR56DK101478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI VOIGHT, BENJAMIN FRANKLIN · 2019 to 2019
$272k
NIDDK NIH HHS K08 DK094968NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK049780NIDDK NIH HHS R01 DK101478NIDDK NIH HHS R56 DK101478NIDDK NIH HHS T32 DK007314
6 · The paper itself

Abstract

PM20D1 is a candidate thermogenic enzyme in mouse fat, with its expression cold-induced and enriched in brown versus white adipocytes. Thiazolidinedione (TZD) antidiabetic drugs, which activate the peroxisome proliferator-activated receptor-γ (PPARγ) nuclear receptor, are potent stimuli for adipocyte browning yet fail to induce

Indexed as

AdipocytesAdipose TissueAmidohydrolasesAnimalsGene ExpressionGene Expression RegulationGenetic VariationHumansMaleMiceObesityPhenotypePPAR gammaThiazolidinediones2,4-thiazolidinedioneAmidohydrolasesPM20D1 protein, humanPPAR gammaThiazolidinedionesadipocyte browninggenetics of gene regulationobesityPM20D1PPARγ

Identifiers

PMID31659023
PMCPMC6859347
OpenAlexW2982575631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.