Evidence map›Paper›PMID 31659010›Full record

ArticleJournal of bacteriology2020

Strain-Dependent RstA Regulation of Clostridioides difficile Toxin Production and Sporulation.

Adrianne N Edwards, Ellen G Krall, Shonna M McBride

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  2. Article
  3. Proline Stickland fermentation supportsApplied and environmental microbiology · 2025
    Article
  4. Article
  5. Review
  6. AApplied and environmental microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Glycine fermentation byInfection and immunity · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. The RgaS-RgaR two-component system promotesbioRxiv : the preprint server for biology · 2023
    Article
  15. Regulatory transcription factors ofCritical reviews in microbiology · 2023
    Review
  16. Microbiology (Reading, England) · 2023
    Review
  17. Article
  18. Emerging microbes & infections · 2022
    Review
  19. A unique class of ZnNature communications · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Adrianne N EdwardsDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia, USA.
Ellen G KrallGenetics and Molecular Biology Graduate Program, Emory University, Atlanta, Georgia, USA.
Shonna M McBrideDepartment of Microbiology and Immunology, Emory University School of Medicine, Emory Antibiotic Resistance Center, Atlanta, Georgia, USA shonna.mcbride@emory.edu.ORCID 0000-0001-6221-714X
Emory University · US

Funding

Host-induced Initiation of Clostridium difficile SporulationR01AI116933 · NIAID · EMORY UNIVERSITY · PI SHONNA M. MCBRIDE · 2015 to 2026
$4.8M
Polymeric Agents for the Treatment of Clostridium difficile InfectionsR33AI121684 · NIAID · EMORY UNIVERSITY · PI GELLMAN, SAMUEL H., MCBRIDE, SHONNA M. · 2018 to 2020
$1.4M
Polymeric Agents for the Treatment of Clostridium difficile InfectionsR21AI121684 · NIAID · EMORY UNIVERSITY · PI GELLMAN, SAMUEL H., MCBRIDE, SHONNA M. · 2016 to 2017
$415k
NIAID NIH HHS R01 AI116933NIAID NIH HHS R21 AI121684NIAID NIH HHS R33 AI121684
6 · The paper itself

Abstract

The anaerobic spore former

Indexed as

Bacterial ProteinsBacterial ToxinsClostridioides difficileGene Expression Regulation, BacterialPromoter Regions, GeneticSpores, BacterialBacterial ProteinsBacterial ToxinsanaerobeClostridioides difficileClostridium difficileCodYgene regulationRstAsporesporulationTcdATcdRtoxin productiontranscriptional regulation

Identifiers

PMID31659010
PMCPMC6941533
OpenAlexW2981523150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.