Evidence map›Paper›PMID 31658973›Full record

ArticleAntimicrobial agents and chemotherapy2019

Reciprocal Modulation of Antiretroviral Drug and Steroid Receptor Function

Sigcinile Dlamini, Michael Kuipa, Kim Enfield, Salndave Skosana, John G Woodland, Johnson Mosoko Moliki, Alexis J Bick, Zephne van der Spuy, Michelle F Maritz, Chanel Avenant and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sigcinile DlaminiDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Michael KuipaDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Kim EnfieldDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Salndave SkosanaDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
John G WoodlandDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Johnson Mosoko MolikiDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Alexis J BickDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Zephne van der SpuyDepartment of Obstetrics and Gynaecology, University of Cape Town, Groote Schuur Hospital, Cape Town, South Africa.
Michelle F MaritzDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Chanel AvenantDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Janet P HapgoodDepartment of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa janet.hapgood@uct.ac.za.
University of Cape Town · ZA

Funding

Combination treatment for protection against HIV1 and pregnancyR01HD083026 · NICHD · UNIVERSITY OF CAPE TOWN · PI HAPGOOD, JANET PATRICIA, HEL, ZDENEK · 2015 to 2019
$2.5M
NICHD NIH HHS R01 HD083026
6 · The paper itself

Abstract

Millions of women are exposed simultaneously to antiretroviral drugs (ARVs) and progestin-based hormonal contraceptives. Yet the reciprocal modulation by ARVs and progestins of their intracellular functions is relatively unexplored. We investigated the effects of tenofovir disoproxil fumarate (TDF) and dapivirine (DPV), alone and in the presence of select steroids and progestins, on cell viability, steroid-regulated immunomodulatory gene expression, activation of steroid receptors, and anti-HIV-1 activity

Indexed as

Anti-Retroviral AgentsCell Line, TumorCell SurvivalHumansInflammationPeripheral Blood Stem CellsProgestinsPyrimidinesReceptors, GlucocorticoidReceptors, ProgesteroneReceptors, SteroidTenofovirTranscription FactorsAnti-Retroviral AgentsDapivirineProgestinsPyrimidinesReceptors, GlucocorticoidReceptors, ProgesteroneReceptors, SteroidTenofovirTranscription FactorsTSC22D3 protein, humanARVcell viabilitydapivirinegene expressionHIV-1inflammationprogesterone receptorprogestinsteroid receptortenofovir disoproxil fumarate

Identifiers

PMID31658973
PMCPMC7187592
OpenAlexW2982530833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.