Evidence map›Paper›PMID 31658971›Full record

ArticleAntimicrobial agents and chemotherapy2019

Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains.

C D Shaw, H Imamura, T Downing, G Blackburn, G D Westrop, J A Cotton, M Berriman, M Sanders, S Rijal, G H Coombs and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular Mechanisms of Drug Resistance inPathogens (Basel, Switzerland) · 2024
    Review
  4. Article
  5. Review
  6. Advanced biomedical research · 2023
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

C D Shaw *Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
H Imamura *Instituut voor Tropische Geneeskunde Nationalestraat, Antwerp, Belgium.
T Downing *School of Biotechnology, Dublin City University, Dublin, Ireland.ORCID 0000-0002-8385-6730
G BlackburnWolfson Wohl Cancer Research Centre, University of Glasgow, Bearsden, United Kingdom.
G D WestropStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
J A CottonWellcome Trust Sanger Institute, Hinxton, United Kingdom.
M BerrimanWellcome Trust Sanger Institute, Hinxton, United Kingdom.
M SandersWellcome Trust Sanger Institute, Hinxton, United Kingdom.
S RijalBP Koirala Institute of Health Sciences, Dharan, Nepal.
G H CoombsStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
J C DujardinInstituut voor Tropische Geneeskunde Nationalestraat, Antwerp, Belgium.
K C CarterStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom k.carter@strath.ac.uk.
University of Strathclyde · GBWellcome Sanger Institute · GBB.P. Koirala Institute of Health Sciences · NPDublin City University · IEInstituut voor Tropische Geneeskunde · BEUniversity of Antwerp · BEUniversity of Glasgow · GB

Funding

Wellcome TrustWellcome Trust 098051
6 · The paper itself

Abstract

Understanding the mechanism(s) underpinning drug resistance could lead to novel treatments to reverse the increased tolerance of a pathogen. In this study, paromomycin (PMM) resistance (PMM

Indexed as

AnimalsAntiprotozoal AgentsDrug ResistanceFemaleGenomicsHumansLeishmania donovaniLeishmaniasis, VisceralLipidomicsMacrophagesMetabolomicsMiceMice, Inbred BALB CNepalParasitic Sensitivity TestsParomomycinAntiprotozoal AgentsParomomycingenomicsLeishmania donovanilipidomicsmetabolomicsparomomycin

Identifiers

PMID31658971
PMCPMC7187574
OpenAlexW2980224393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.