ArticleArchives of craniofacial surgery2019
Wound healing effect of regenerated oxidized cellulose versus fibrin sealant patch: An in vivo study.
Article in Archives of craniofacial surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- In Vitro Evaluation of Anti-Inflammatory and Antioxidant Properties of a Novel Calcium Alginate-Zinc Hemostatic Biomaterial.Journal of functional biomaterials · 2026Article
- Biological Macromolecule-Based Dressings for Combat Wounds: From Collagen to Growth Factors-A Review.Medical sciences (Basel, Switzerland) · 2025Review
- Recent Trends in the Application of Cellulose-Based Hemostatic and Wound Healing Dressings.Journal of functional biomaterials · 2025Review
- Regenerated Oxidized Cellulose as a Sealant and Adhesive in Endoscopic Endonasal Skull Base Reconstruction.International archives of otorhinolaryngology · 2025Article
- Bioactive hemostatic materials: a new strategy for promoting wound healing and tissue regeneration.MedComm · 2025Review
- Injectable, Antibacterial, and Hemostatic Tissue Sealant Hydrogels.Advanced healthcare materials · 2023Article
- Multisuture craniosynostosis: a case report of unusual presentation of chromosome 14q32 deletion.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- A new hemostatic agent composed of ZnBioactive materials · 2022Article
- Topical hemostatic agents in neurosurgery, a comprehensive review: 15 years update.Neurosurgical review · 2022Review
- Biological Application of Novel Biodegradable Cellulose Composite as a Hemostatic Material.Mediators of inflammation · 2022Article
- Biological compatibility of oxidized cellulose vs. porcine gelatin to control bleeding in liver lesions in rats.Acta cirurgica brasileira · 2022Article
- Evaluation of mesenchymal stem cells in the healing of anastomosed carotid arteries.American journal of stem cells · 2021Article
- Novel fibrin-fibronectin matrix accelerates mice skin wound healing.Bioactive materials · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTopical hemostatic agents are used when ligation, electrocauterization, or other conventional hemostatic methods are impractical. Because a hemostatic agent is a foreign body, it can cause foreign body reactions, inflammation, and infections that can interfere with the wound healing process. Therefore, we should select hemostatic agents after considering their effects on wound healing. Here, we compared the effects of hemostatic agents on wound healing in a rectus abdominis muscle defect in rats.
methodsTwelve Sprague Dawley rats were subjected to creation of a 6 × 6 mm defect in the rectus abdominis muscle and divided into four groups: control group; group A, Tachosil fibrin sealant patch; group B, Surgicel Fibrillar oxidized regenerated cellulose; and group C, Surgicel Snow oxidized regenerated cellulose. For the histologic analysis, biopsies were performed on the 3rd, 7th, and 27th days.
resultsThe foreign body reaction was the weakest in group A and most significant in group C. The inflammatory cell infiltration was the weakest in group A and similar in groups B and C. Muscle regeneration differed among periods. The rats in group A were the most active initially, while those in group C showed prolonged activity.
conclusionTachosil and Surgicel administration increased inflammation via foreign body reactions, but the overall wound healing process was not significantly affected. The increased inflammation in the Surgicel groups was due to a low pH. We recommend using Tachosil, because it results in less intense foreign body reactions than Surgicel and faster wound healing due to the fibrin action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.