Evidence map›Paper›PMID 31658723›Full record

ReviewMolecules (Basel, Switzerland)2019

Stapled Peptides-A Useful Improvement for Peptide-Based Drugs.

Mattia Moiola, Misal G Memeo, Paolo Quadrelli

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Enhancement of Structural Stability and IgG Affinity of aAntibodies (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Article
  11. Stapling of β-Glucans Increases Antibody Binding.Journal of the American Chemical Society · 2025
    Article
  12. Review
  13. Thymic Bmi-1 hampers γδT17 generation and its derived RORγt-IL-17A signaling to delay cardiac aging.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mattia MoiolaDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. mattia.moiola01@universitadipavia.it.
Misal G MemeoDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. misalgmemeo@gmail.com.
Paolo QuadrelliDepartment of Chemistry, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. paolo.quadrelli@unipv.it.ORCID 0000-0001-5369-9140
University of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide-based drugs, despite being relegated as niche pharmaceuticals for years, are now capturing more and more attention from the scientific community. The main problem for these kinds of pharmacological compounds was the low degree of cellular uptake, which relegates the application of peptide-drugs to extracellular targets. In recent years, many new techniques have been developed in order to bypass the intrinsic problem of this kind of pharmaceuticals. One of these features is the use of

Indexed as

Drug DesignPeptidesProtein Conformation, alpha-HelicalPeptidescellular uptakehelicitypeptide drugsstapled peptidestructurally constrained peptide

Identifiers

PMID31658723
PMCPMC6832507
OpenAlexW2980127096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.