Evidence map›Paper›PMID 31658592›Full record

ArticleInternational journal of molecular sciences2019

Receptor Heterodimerization and Co-Receptor Engagement in TLR2 Activation Induced by MIC1 and MIC4 from

Flávia Costa Mendonça-Natividade, Carla Duque Lopes, Rafael Ricci-Azevedo, Aline Sardinha-Silva, Camila Figueiredo Pinzan, Ana Claudia Paiva Alegre-Maller, Lilian L Nohara, Alan B Carneiro, Ademilson Panunto-Castelo, Igor C Almeida and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. HarnessingAnnals of medicine · 2026
    Review
  3. A novel anti-Microbiology spectrum · 2026
    Article
  4. Recombinant Microneme Proteins MIC1 and MIC4 fromPathogens (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Glycosylation Analysis of Feline Small Intestine FollowingAnimals : an open access journal from MDPI · 2022
    Article
  9. Diverse Roles of TgMIC1/4/6 in theFrontiers in microbiology · 2021
    Review
  10. Microneme Proteins 1 and 4 FromFrontiers in immunology · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Flávia Costa Mendonça-NatividadeLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. flavia.bioquimica@usp.br.ORCID 0000-0001-5239-6965
Carla Duque LopesLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. cduquelopes@gmail.com.
Rafael Ricci-AzevedoLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. rrazevedo@gmail.com.ORCID 0000-0002-0020-6530
Aline Sardinha-SilvaLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. aline.sardinhadasilva@nih.gov.
Camila Figueiredo PinzanLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. capinzan@gmail.com.
Ana Claudia Paiva Alegre-MallerLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. anapaiva@fag.edu.br.
Lilian L NoharaBorder Biomedical Research Center (BBRC), Department of Biological Sciences, University of Texas at El Paso (UTEP), El Paso, TX 79968, USA. llnohara@msl.ubc.ca.
Alan B CarneiroBorder Biomedical Research Center (BBRC), Department of Biological Sciences, University of Texas at El Paso (UTEP), El Paso, TX 79968, USA. alan.fiocruz@gmail.com.
Ademilson Panunto-CasteloDepartment of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo USP (FFCLRP/USP), Ribeirão Preto SP 14040-900, Brazil. apcastelo@usp.br.ORCID 0000-0003-0148-0133
Igor C AlmeidaBorder Biomedical Research Center (BBRC), Department of Biological Sciences, University of Texas at El Paso (UTEP), El Paso, TX 79968, USA. icalmeida@utep.edu.
Maria Cristina Roque-BarreiraLaboratory of Immunochemistry and Glycobiology, Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo (FMRP/USP), Ribeirão Preto SP 14049-900, Brazil. mcrbarre@fmrp.usp.br.ORCID 0000-0001-7425-0908
Universidade de São Paulo · BRThe University of Texas at El Paso · USUniversidade de Ribeirão Preto · BRUniversidade Federal do Rio de Janeiro · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #475357/2013-2;#306298/2013-9Fundação de Amparo à Pesquisa do Estado de São Paulo #2013/04088-0; #2014/13324-1; 2008/52130-7;2017/02998-0NIMHD NIH HHS G12MD007592;2G12MD007592
6 · The paper itself

Abstract

The microneme organelles of

Indexed as

DimerizationAnimalsCD36 AntigensCell Adhesion MoleculesCytokinesFemaleGene Knockdown TechniquesHEK293 CellsHumansLipopolysaccharide ReceptorsMacrophagesMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMiceMice, Inbred C57BLNF-kappa BCD14 protein, humanCD36 AntigensCD36 protein, humanCell Adhesion MoleculesCytokinesLipopolysaccharide ReceptorsMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMIC1 protein, Toxoplasma gondiiMIC4 protein, Toxoplasma gondiiNF-kappa Bp38 Mitogen-Activated Protein KinasesProtozoan ProteinsTLR1 protein, humanTLR2 protein, humanTLR6 protein, humanToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 6CD14CD36microneme proteinsTLR co-receptorsTLR heterodimerizationToll-like receptor 2Toxoplasma gondii

Identifiers

PMID31658592
PMCPMC6829480
OpenAlexW2979956639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.