ArticleNMR in biomedicine2021
MEGA-PRESS of GABA+: Influences of acquisition parameters.
Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Functional MRS studies of GABA and glutamate/Glx - A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder.Translational psychiatry · 2021Pooled it
- Ultra-high field magnetic resonance spectroscopy study of transcranial magnetic stimulation treatment in adolescents with depression.BMC psychiatry · 2026Trial
- Reproducibility of Metabolic Mapping Using 2D Multi-Slice Short-TE and GABA-Edited Spin-Echo MRSI at 3T in a Single Protocol.NMR in biomedicine · 2026Article
- SMART MRS: A Simulated MEGA-PRESS ARTifacts toolbox for GABA-edited MRS.Magnetic resonance in medicine · 2025Article
- Disentangling metabolic and neurovascular timescales supporting cognitive processes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology.Molecular psychiatry · 2025Article
- GABA-edited MEGA-PRESS at 3 T: Does a measured macromolecule background improve linear combination modeling?Magnetic resonance in medicine · 2024Article
- A comprehensive guide to MEGA-PRESS for GABA measurement.Analytical biochemistry · 2023Review
- Quantification of GABA concentration measured noninvasively in the human posterior cingulate cortex with 7 T ultra-short-TE MR spectroscopy.Magnetic resonance in medicine · 2023Article
- Brain total creatine differs between primary progressive aphasia (PPA) subtypes and correlates with disease severity.Neurobiology of aging · 2023Article
- Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study.The international journal of neuropsychopharmacology · 2023Article
- MRSCloud: A cloud-based MRS tool for basis set simulation.Magnetic resonance in medicine · 2022Article
- Quantifying GABA in Addiction: A Review of Proton Magnetic Resonance Spectroscopy Studies.Brain sciences · 2022Review
- Comparison of seven modelling algorithms for γ-aminobutyric acid-edited proton magnetic resonance spectroscopy.NMR in biomedicine · 2022Article
- γ-aminobutyric acid measurement in the human brain at 7 T: Short echo-time or Mescher-Garwood editing.NMR in biomedicine · 2022Article
- Decreased Brain GABA Levels in Patients with Migraine Without Aura: An Exploratory Proton Magnetic Resonance Spectroscopy Study.Neuroscience · 2022Article
- Influence of editing pulse flip angle on J-difference MR spectroscopy.Magnetic resonance in medicine · 2022Article
- Comparison of linear combination modeling strategies for edited magnetic resonance spectroscopy at 3 T.NMR in biomedicine · 2022Article
- A comparative magnetic resonance spectroscopy study of GABA+ and glutamate referenced to creatine and phosphocreatine in the left dorsolateral prefrontal cortex of perimenopausal women and women of reproductive age.Frontiers in psychiatry · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
γ-aminobutyric acid (GABA) was the first molecule that was edited with MEGA-PRESS. GABA edited spectroscopy is challenged by limited selectivity of editing pulses. Coediting of resonances from macromolecules (MM) is the greatest single limitation of GABA edited spectroscopy. In this contribution, relative signal contributions from GABA, MM and homocarnosine to the total MEGA-PRESS edited signal at ~3 ppm, i.e., GABA+, are simulated at 3 tesla using several acquisition schemes. The base scheme is modeled after those currently supplied by vendors: it uses typical pulse shapes and lengths, it minimizes the first echo time (TE), and the delay between the editing pulses is kept at TE/2. Edited spectra are simulated for imperfect acquisition parameters such as incorrect frequency, larger chemical shift displacement, incorrect transmit B
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.