ArticlePLoS computational biology2019
Matrix feedback enables diverse higher-order patterning of the extracellular matrix.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The influence of cell phenotype on collective cell invasion into the extracellular matrix.Bulletin of mathematical biology · 2025Article
- Allometric cell spreading and the geometrical control of focal adhesion collective organization.Biophysical journal · 2025Article
- Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment.PLoS computational biology · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Autocrine IL-6 drives cell and extracellular matrix anisotropy in scar fibroblasts.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Article
- Crisscross multilayering of cell sheets.PNAS nexus · 2023Article
- Fibroblast-derived matrix models desmoplastic properties and forms a prognostic signature in cancer progression.Frontiers in immunology · 2023Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Mesoscience in cell biology and cancer research.Cancer innovation · 2022Review
- Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells.Scientific reports · 2021Article
- CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer.Scientific reports · 2021Article
- A FIJI macro for quantifying pattern in extracellular matrix.Life science alliance · 2021Article
- A phenotypic switch in the dispersal strategy of breast cancer cells selected for metastatic colonization.Proceedings. Biological sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The higher-order patterning of extra-cellular matrix in normal and pathological tissues has profound consequences on tissue function. Whilst studies have documented both how fibroblasts create and maintain individual matrix fibers and how cell migration is altered by the fibers they interact with, a model unifying these two aspects of tissue organization is lacking. Here we use computational modelling to understand the effect of this interconnectivity between fibroblasts and matrix at the mesoscale level. We created a unique adaptation to the Vicsek flocking model to include feedback from a second layer representing the matrix, and use experimentation to parameterize our model and validate model-driven hypotheses. Our two-layer model demonstrates that feedback between fibroblasts and matrix increases matrix diversity creating higher-order patterns. The model can quantitatively recapitulate matrix patterns of tissues in vivo. Cells follow matrix fibers irrespective of when the matrix fibers were deposited, resulting in feedback with the matrix acting as temporal 'memory' to collective behaviour, which creates diversity in topology. We also establish conditions under which matrix can be remodelled from one pattern to another. Our model elucidates how simple rules defining fibroblast-matrix interactions are sufficient to generate complex tissue patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.