Evidence map›Paper›PMID 31657825›Full record

ArticleJAMA neurology2020

Epidemiology of Dementia and Alzheimer Disease in Individuals With Down Syndrome.

Eric Rubenstein, Sigan Hartley, Lauren Bishop

Registry-linked trialAbstract read
In one paragraph

Article in JAMA neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07047963 (Neuropsychological Evaluation in Intellectual Disability), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07047963 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Neuropsychological Evaluation in Intellectual Disability

TypeobservationalSponsorCentral Hospital, Nancy, FranceRan2025 to 2026Enrolled40ConditionsDown Syndrome (Trisomy 21), Neuropsychology, Cognitive Aging, Alzheimer DiseaseArmsENDI (Neuropsychological Evaluation in Intellectual Disability)
3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Review
  3. The forgotten population: Early-onset Alzheimer's in people with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Article
  6. A Review of Clinical Trials in Down Syndrome.International review of research in developmental disabilities · 2025
    Article
  7. Review
  8. Occurrence of mosaic Down syndrome and prevalence of co-occurring conditions in Medicaid enrolled adults, 2016-2019.American journal of medical genetics. Part C, Seminars in medical genetics · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Healthcare and Behavior Changes for Adults With Down Syndrome 1-Year Into COVID-19.American journal on intellectual and developmental disabilities · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Role of tau deposition in early cognitive decline in Down syndrome.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
  19. Cognitive outcome measures for tracking Alzheimer's disease in Down syndrome.International review of research in developmental disabilities · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eric RubensteinWaisman Center, University of Wisconsin-Madison, Madison.
Sigan HartleyWaisman Center, University of Wisconsin-Madison, Madison.
Lauren BishopWaisman Center, University of Wisconsin-Madison, Madison.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Career Development CoreKL2TR002374 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Bo Liu, Marin Leigh Schweizer · 2017 to 2026
$9.7M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0M
NCATS NIH HHS KL2 TR000428NCATS NIH HHS KL2 TR002374NCATS NIH HHS UL1 TR002373NICHD NIH HHS T32 HD007489
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAlzheimer DiseaseDementiaDown SyndromeFemaleHumansIncidenceMaleMiddle AgedPrevalence

Identifiers

PMID31657825
PMCPMC6820036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.