Evidence map›Paper›PMID 31657647›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Inositol polyphosphate multikinase is a metformin target that regulates cell migration.

Becky Tu-Sekine, Abinash Padhi, Sunghee Jin, Srivathsan Kalyan, Karanpreet Singh, Matthew Apperson, Rakesh Kapania, Soojung Claire Hur, Amrinder Nain, Sangwon F Kim

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  7. Review
  8. Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds.American journal of physiology. Cell physiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Becky Tu-SekineDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Abinash PadhiDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Sunghee JinDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Srivathsan KalyanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Karanpreet SinghDepartment of Aerospace and Ocean Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Matthew AppersonDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Rakesh KapaniaDepartment of Aerospace and Ocean Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Soojung Claire HurDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Amrinder NainDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
Sangwon F KimDepartment of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USVirginia Tech · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin has been shown to alter cell adhesion protein expression, which is thought to play a role in its observed antitumor properties. We found that metformin treatment down-regulated integrin β1 concomitant with the loss of inositol polyphosphate multikinase (IPMK) in murine myocytes, adipocytes, and hepatocytes. To determine if IPMK was upstream of integrin β1 expression, we examined IPMK

Indexed as

AnimalsCell MovementDown-RegulationFibroblastsFocal Adhesion Kinase 1Gene Expression Regulation, EnzymologicHypoglycemic AgentsIntegrin beta1MetforminMiceMice, KnockoutPhosphotransferases (Alcohol Group Acceptor)Focal Adhesion Kinase 1Hypoglycemic Agentsinositol polyphosphate multikinaseIntegrin beta1MetforminPhosphotransferases (Alcohol Group Acceptor)Ptk2 protein, mouseadhesionextracellular matrixfocal adhesion kinaseintegrinnanonet force microscopy

Identifiers

PMID31657647
PMCPMC6894044
OpenAlexW2981346204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.