Evidence map›Paper›PMID 31657634›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Disease Progression Modeling in Chronic Obstructive Pulmonary Disease.

Alexandra L Young, Felix J S Bragman, Bojidar Rangelov, MeiLan K Han, Craig J Galbán, David A Lynch, David J Hawkes, Daniel C Alexander, John R Hurst, COPDGene Investigators

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. COPD stage progression and regression: a multistate transition analysis of the COPDGene cohort.American journal of respiratory and critical care medicine · 2026
    Article
  5. Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Navigating the Progression of Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2025
    Article
  14. Observational
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Alexandra L YoungCentre for Medical Image Computing.ORCID 0000-0002-7772-781X
Felix J S BragmanCentre for Medical Image Computing.ORCID 0000-0001-5910-2966
Bojidar RangelovCentre for Medical Image Computing.ORCID 0000-0001-7017-1575
MeiLan K HanArtificial Medical Intelligence Group, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.ORCID 0000-0002-9095-4419
Craig J GalbánPulmonary and Critical Care, and.ORCID 0000-0001-5596-7487
David A LynchCenter for Molecular Imaging, University of Michigan, Ann Arbor, Michigan; and.
David J HawkesCentre for Medical Image Computing.ORCID 0000-0001-7151-1762
Daniel C AlexanderCentre for Medical Image Computing.ORCID 0000-0003-2439-350X
John R HurstDepartment of Radiology, National Jewish Health, Denver, Colorado.ORCID 0000-0002-7246-6040
COPDGene Investigators
Centre for Biomedical Engineering and Physics · SEKing's College London · GBCentre for Sight · INNational Jewish Health · USPulmonary and Critical Care Associates · USUniversity of Michigan · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
An Early Imaging Marker of EmphysemaR01HL139690 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GALBAN, CRAIG J · 2019 to 2022
$1.9M
Clinical significance and genetic determinants of novel imaging measures of emphysema distribution in 9,743 smokersK08HL141601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI EL BOUEIZ, ADEL · 2018 to 2022
$853k
Medical Research Council MR/T027800/1NHLBI NIH HHS K08 HL141601NHLBI NIH HHS R01 HL139690NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NIH HHS S10 OD018526
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Disease ProgressionModels, TheoreticalTomography, X-Ray ComputedAgedFemaleHumansMaleMiddle AgedPulmonary Disease, Chronic Obstructivebronchitischronic obstructive pulmonary diseaseclusteringCT imagingemphysema

Identifiers

PMID31657634
PMCPMC6999095
OpenAlexW2982614698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.