ArticleEMBO molecular medicine2019
Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
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In one paragraph
Article in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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39citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The Role of Hydrogen Sulfide (HInternational journal of molecular sciences · 2023Pooled it
- Intragenic deletions from whole genome sequencing of 1054 suicide deaths.Research square · 2026Article
- Antidepressant Augmentation of Antipsychotic Treatment in Schizophrenia: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Hydrogen sulfide/polysulfides signaling and neuronal diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- The Potential of Hair Matrix for Biomarker Analysis in Schizophrenia.International journal of molecular sciences · 2025Review
- Hydrogen Sulfide (HInternational journal of molecular sciences · 2025Review
- Hydrogen Sulfide Alleviates Schizophrenia-Like Behavior Through Regulating Apoptosis by S-Sulfhydrylation Modification.CNS neuroscience & therapeutics · 2025Article
- Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.Journal of oral microbiology · 2025Review
- The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood.Pharmacological reports : PR · 2024Article
- S-Allyl-L-Cysteine Affects Cell Proliferation and Expression of HBiomolecules · 2024Article
- Hydrogen Sulfide (HBiomolecules · 2024Review
- Hydrogen sulfide and polysulfides induce GABA/glutamate/D-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity.Scientific reports · 2023Article
- Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer's Disease: A Recent Systematic Review.International journal of molecular sciences · 2023Review
- Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions.Molecular psychiatry · 2023Review
- The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders.International journal of molecular sciences · 2023Review
- Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- SOD1 is an essential HProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Schizophrenia Etiological Factors and Their Correlation with the Imbalance of the Immune System: An Update.Galen medical journal · 2023Review
- SELENBP1 overexpression in the prefrontal cortex underlies negative symptoms of schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
37 authors at 15 institutions in 2 countries.
Masayuki IdeLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Tetsuo OhnishiLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Manabu ToyoshimaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Shabeesh BalanLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.ORCID 0000-0002-1098-1290
Motoko MaekawaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Chie Shimamoto-MitsuyamaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Yoshimi IwayamaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Hisako OhbaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Akiko WatanabeLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Takashi IshiiResearch& Development Department, MCBI Inc, Tsukuba, Ibaraki, Japan.
Norihiro ShibuyaDepartment of Pharmacology, Sanyo-Onoda City University, Sanyo-Onoda, Yamaguchi, Japan.
Yuka KimuraDepartment of Pharmacology, Sanyo-Onoda City University, Sanyo-Onoda, Yamaguchi, Japan.
Yasuko HisanoLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Yui MurataDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tomonori HaraLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Momo MorikawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kenji HashimotoDivision of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.
Yayoi NozakiLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Tomoko ToyotaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Yuina WadaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Yosuke TanakaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Akinori NishiDepartment of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
Shigeyoshi FujisawaLaboratory for Systems Neurophysiology, RIKEN Center for Brain Science, Wako, Saitama, Japan.
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.
Masanari ItokawaCenter for Medical Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Nobutaka HirokawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-0081-5264
Yasuto KuniiDepartment of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Hirooki YabeDepartment of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Kazuya IwamotoDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kohji MenoResearch& Development Department, MCBI Inc, Tsukuba, Ibaraki, Japan.
Takuya KatagiriDepartment of Pharmacy, Faculty of Pharmacy, Iryo Sosei University, Iwaki, Fukushima, Japan.
Brian DeanThe Florey Institute of Neuroscience and Mental Health, Howard Florey Laboratories, The University of Melbourne, Parkville, Vic., Australia.
Kazuhiko UchidaDepartment of Molecular Oncology, Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hideo KimuraDepartment of Pharmacology, Sanyo-Onoda City University, Sanyo-Onoda, Yamaguchi, Japan.
Takeo YoshikawaLaboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan.ORCID 0000-0003-2791-6679
RIKEN Center for Brain Science · JPNational Center of Neurology and Psychiatry · JPThe University of Tokyo · JPFukushima Medical University · JPKumamoto University · JPUniversity of Tsukuba · JPCenter for Forensic Mental Health, Chiba University · JPIRYO Sosei University · JPKeio University · JPKurume University · JPNiigata University · JPOchanomizu University · JPThe University of Melbourne · AUTohoku University · JPTokyo Metropolitan Institute of Medical Science · JP
Funding
Japan Agency for Medical Research and Development (AMED) 19dm0107086Japan Agency for Medical Research and Development (AMED) 19dm0107107Japan Agency for Medical Research and Development (AMED) JP18dm0107083Japan Agency for Medical Research and Development (AMED) JP18dm0107085Japan Agency for Medical Research and Development (AMED) JP19dm0107083Japan Agency for Medical Research and Development (AMED) JP19dm0107119Japan Agency for Medical Research and Development (AMED) JP19dm0908001MEXT|Japan Society for the Promotion of Science (JSPS) JP16H06277MEXT|Japan Society for the Promotion of Science (JSPS) JP17H01574MEXT|Japan Society for the Promotion of Science (JSPS) JP18H05428MEXT|Japan Society for the Promotion of Science (JSPS) JP18H05435
Abstract
Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as-yet-unknown pathophysiologies of schizophrenia, we undertook proteomics analysis of the brain in these strains, and detected elevated levels of Mpst, a hydrogen sulfide (H
Indexed as
AnimalsElectrophoresis, Gel, Two-DimensionalEnergy MetabolismEpigenomicsHydrogen SulfideMaleMiceProteomicsSchizophreniaSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSulfidesHydrogen SulfidepolysulfideSulfidesenergy metabolismepigeneticshydrogen sulfide and polysulfidesprepulse inhibitionproteomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.