Evidence map›Paper›PMID 31657484›Full record

ArticleScandinavian journal of immunology2020

Mannose-capped lipoarabinomannan-induced B10 cells decrease severity of dextran sodium sulphate-induced inflammatory bowel disease in mice.

Chun-Hui Yuan, Xin Li, Liang Luo, Ya-Ping Wang, Dong-Li Zhang, Kai-Liang Zhou, Xiao-Lian Zhang, Qin Pan

Open access · hybridAbstract read
In one paragraph

Article in Scandinavian journal of immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chun-Hui YuanDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.ORCID https://orcid.org/0000-0003-4382-2541
Xin LiDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Liang LuoDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Ya-Ping WangDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Dong-Li ZhangDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Kai-Liang ZhouThe Eighth Hospital of Wuhan, Wuhan, China.
Xiao-Lian ZhangDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.
Qin PanDepartment of Immunology, State Key Laboratory of Virology and Medical Research Institute, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Basic Medical Sciences, Wuhan, China.ORCID https://orcid.org/0000-0002-4210-2852
Wuhan University · CNThe Eighth Hospital of Xi'an · CN

Funding

CAMS Innovation Funding For Medical Sciences 2016-I2M-1-013CAMS Innovation Funding For Medical Sciences 2016-I2M-2-006Medical Science Advancement Program 2018002National Key R&D Program of China 2018YFA0507603National Natural Science Foundation of China 21572173National Natural Science Foundation of China 31221061National Natural Science Foundation of China 31370197National Natural Science Foundation of China 31770145National Natural Science Foundation of China 81501377National Natural Science Foundation of China 81971908National Outstanding Youth Foundation of China 81025008National Science and Technology Major Project 2012ZX10003002-015National Science and Technology Major Project 2017ZX10201301-006Natural Science Foundation Key Project of Hubei Province 2016CFA062Outstanding Youth Foundation of Hubei Province 2018CFA037The Innovative Talent Funding Project 2042019kf0196The Major Projects of Technological Innovation of Hubei Province 2016ACA150
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic, non-specific, inflammatory gastrointestinal disease that mainly consists of Crohn's disease and ulcerative colitis. However, the aetiology and pathogenesis of IBD are still unclear. B10 (IL-10 producing regulatory B) cells, a subset of regulatory B cells, are known to contribute to intestinal homeostasis and the aberrant frequency of B10 cells is associated with IBD. We have recently reported that B10 cells can be induced by ManLAM (mannose-capped lipoarabinomannan), a major cell-wall lipoglycan of M tb (Mycobacterium tuberculosis). In the current study, the ManLAM-induced B10 cells were adoptively transferred into IL(interleukin)-10

Indexed as

AnimalsB-Lymphocytes, RegulatoryDextran SulfateDisease Models, AnimalHumansImmune ToleranceInflammatory Bowel DiseasesInterleukin-10LipopolysaccharidesMannoseMiceMice, KnockoutMycobacterium tuberculosisTh1 CellsDextran SulfateInterleukin-10lipoarabinomannanLipopolysaccharidesMannoseB cellsIL-10inflammatory bowel diseaseManLAM

Identifiers

PMID31657484
PMCPMC7050505
OpenAlexW2982460189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.