SynthesisJournal of the American Heart Association2019
Mortality Risk in Acute Ischemic Stroke Patients With Large Vessel Occlusion Treated With Mechanical Thrombectomy.
Synthesis in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- 2025 update to European Stroke Organisation (ESO) guideline on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage.European stroke journal · 2026Guideline
- Mechanical thrombectomy for acute ischemic stroke: systematic review and meta-analysis.Einstein (Sao Paulo, Brazil) · 2022Pooled it
- Mortality Risk in Acute Ischemic Stroke Patients With Large Vessel Occlusion Treated With Mechanical Thrombectomy.Journal of the American Heart Association · 2019Pooled it
- Bibliometric Analysis of Global Research Activity on Stroke Mortality: 1961-2024.Neuroepidemiology · 2026Article
- Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes.Stroke · 2025Observational
- Outcomes of mechanical thrombectomy at a single-centre tertiary level public healthcare hospital in South Africa.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Postoperative blood glucose increase can predict all-cause mortality within 3 months after successful interventional recanalization in patients with acute large vessel occlusion cerebral infarction.Diabetology & metabolic syndrome · 2025Article
- Risk factors and operative risk of large vessel occlusion and stroke during cardiac surgery.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Blood Pressure Management Following Endovascular Stroke Treatment: A Feasibility Trial and Meta-Analysis of Outcomes.Stroke (Hoboken, N.J.) · 2024Article
- Overview of systematic reviews comparing endovascular to best medical treatment for large-vessel occlusion acute ischaemic stroke: an umbrella review.Therapeutic advances in neurological disorders · 2024Review
- Characteristics of Mortality After Endovascular Thrombectomy in Patients with Acute Ischemic Stroke.Clinical interventions in aging · 2024Article
- Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions.Neurology · 2023Article
- Timing and causes of death after endovascular thrombectomy in patients with acute ischemic stroke.European stroke journal · 2023Observational
- Predictors of Decompressive Hemicraniectomy in Successfully Recanalized Patients With Anterior Circulation Emergency Large-Vessel Occlusion.Stroke (Hoboken, N.J.) · 2022Article
- Neurovascular and infectious disease phenotype of acute stroke patients with and without COVID-19.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Association of the 24-Hour National Institutes of Health Stroke Scale After Mechanical Thrombectomy With Early and Long-Term Survival.Stroke (Hoboken, N.J.) · 2022Article
- Safety and efficacy of endovascular thrombectomy in acute ischemic stroke treated with anticoagulants: a systematic review and meta-analysis.Thrombosis journal · 2022Article
- Neutrophil extracellular traps regulate ischemic stroke brain injury.The Journal of clinical investigation · 2022Article
- Article
- Acute ischemic stroke treatment model for Poland in the mechanical thrombectomy era - which way to go?Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Recent randomized controlled clinical trials have provided solid evidence that mechanical thrombectomy (MT) coupled with best medical therapy (BMT) improve functional outcomes of acute ischemic stroke patients with large vessel occlusion compared with BMT alone. However, they provided inconclusive evidence on the benefit of MT on mortality. Methods and Results We evaluated the association of MT+BMT compared with BMT with the risk of 3-month mortality using aggregate data from all available randomized controlled clinical trials. We also sought to identify potential predictors on the mortality risk and performed univariate meta-regression analyses. Our literature search identified 11 eligible randomized controlled clinical trials, including a total of 2460 patients. The pooled rates of 3-month mortality were 15% (95% CI:12%-19%) and 19% (95% CI:16%-23%), respectively, in the MT+BMT and BMT groups. In the overall analysis MT+BMT was associated with a significantly lower risk for 3-month mortality compared with BMT (risk ratio=0.83, 95% CI:0.69-0.99;
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.