ArticleAnnals of clinical and translational neurology2019
Electroencephalographic biomarkers of epilepsy development in patients with acute brain injury: a matched, parallel cohort study.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The Role of Electroencephalography in Predicting Post-Stroke Seizures and an Updated Prognostic Model (SeLECT-EEG).Annals of neurology · 2025Article
- Management and Outcomes in Confirmed or Suspected Acute Symptomatic Seizure: Role of Structured Outpatient Care.Annals of clinical and translational neurology · 2025Article
- Editorial: Acute symptomatic seizures and epileptiform abnormalities: Management and outcomes.Frontiers in neurology · 2023Article
- Article
- Acute epileptiform abnormalities are the primary predictors of post-stroke epilepsy: a matched, case-control study.Annals of clinical and translational neurology · 2022Article
- Association of Epileptiform Abnormality on Electroencephalography with Development of Epilepsy After Acute Brain Injury.Neurocritical care · 2021Article
- Long-term continuation of anti-seizure medications after acute stroke.Annals of clinical and translational neurology · 2021Article
- Seizures and epilepsy after intracerebral hemorrhage: an update.Journal of neurology · 2021Article
- Update on the Neuroimaging and Electroencephalographic Biomarkers of Epileptogenesis: A Literature Review.Frontiers in neurology · 2021Review
- Seizures and Interictal Epileptiform Activity in the Rat Collagenase Model for Intracerebral Hemorrhage.Frontiers in neuroscience · 2021Article
- Continuous electroencephalography characteristics and acute symptomatic seizures in COVID-19 patients.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Article
- Post-acute symptomatic seizure (PASS) clinic: A continuity of care model for patients impacted by continuous EEG monitoring.Epilepsia open · 2020Article
- Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to investigate if highly epileptic electroencephalogram (EEG) findings in patients with acute brain injury increase the long-term risk of epilepsy development.
methodsAdults patients, lacking epilepsy history, with electrographic seizures or lateralized periodic discharges (LPDs) (cases) were identified and matched based on age, mental status, and etiology with the ones lacking any epileptiform activity (controls) on continuous EEG (cEEG) during hospitalization. The primary outcome of clinical seizures after hospital discharge and their antiepileptic drug (AED) status was determined using a telephonic interview. Logistic regression models using generalized estimating equations to account for the matched nature of the data were performed.
resultsA total of 70 cases [16 (22.9%) "LPDs only," 34 (48.6%) "electrographic seizure only," and 20 (28.6%) "both"] and controls were enrolled. A total of 22 (31.4%) cases developed epilepsy after a mean follow-up duration of 20.6 ± 5.0 months compared to three (4.3%) controls. After adjusting for cEEG indication and follow-up duration, the odds of cases developing epilepsy were almost 15 times higher compared to the controls (OR = 14.8, 95% CI = 2.4-92.3, P = 0.004). This elevated risk was despite a 10 times higher likelihood of cases to be taking AEDs at the last follow-up (OR = 10.34, 95% CI = 3.7-29, P < 0.001).
interpretationHighly epileptic EEG findings in patients with acute brain injury may serve as prognostic biomarkers of epilepsy development. Although prospective studies are required to confirm our findings, it seems that with epilepsy developing in almost one-third cases in less than 2-year follow-up period, such patients may potentially be ideal candidates for epilepsy prevention clinical trials.
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