Evidence map›Paper›PMID 31657126›Full record

ArticleAnnals of clinical and translational neurology2019

Intrathecal cytokine profile in neuropathy with anti-neurofascin 155 antibody.

Hidenori Ogata, Xu Zhang, Ryo Yamasaki, Takayuki Fujii, Akira Machida, Nobutoshi Morimoto, Kenichi Kaida, Teruaki Masuda, Yukio Ando, Motoi Kuwahara and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Antibody-Mediated Nodo- and Paranodopathies.Journal of clinical medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Hidenori OgataDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0001-8932-9731
Xu ZhangDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ryo YamasakiDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.ORCID 0000-0003-2071-7861
Takayuki FujiiDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Akira MachidaDepartment of Neurology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Nobutoshi MorimotoDepartment of Neurology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
Kenichi KaidaDepartment of Neurology, Anti-aging and Vascular Medicine, National Defense Medical College, Saitama, Japan.
Teruaki MasudaDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Yukio AndoDepartment of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Motoi KuwaharaDepartment of Neurology, School of Medicine, Kinki University, Osaka, Japan.
Susumu KusunokiDepartment of Neurology, School of Medicine, Kinki University, Osaka, Japan.
Yuri NakamuraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takuya MatsushitaDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Noriko IsobeDepartment of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jun-Ichi KiraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kyushu University · JPKindai University · JPKumamoto University · JPKagawa Prefectural Central Hospital · JPNational Defense Medical College · JPTsuchiura Kyodo General Hospital · JP

Funding

Japan Agency for Medical Research and Development JP17ek0109115Japan Agency for Medical Research and Development JP18ek0109376JSPS KAKENHI JP18K15454
6 · The paper itself

Abstract

objectiveTo characterize the CSF cytokine profile in chronic inflammatory demyelinating polyneuropathy (CIDP) patients with IgG4 anti-neurofascin 155 (NF155) antibodies (NF155

methodsTwenty-eight CSF cytokines/chemokines/growth factors were measured by multiplexed fluorescent immunoassay in 35 patients with NF155

resultsCSF CXCL8/IL-8, IL-13, TNF-α, CCL11/eotaxin, CCL2/MCP-1, and IFN-γ were significantly higher, while IL-1β, IL-1ra, and G-CSF were lower, in NF155

interpretationIntrathecal upregulation of type 2 helper T (Th2) cell cytokines is characteristic of IgG4 NF155

Indexed as

AutoantibodiesAdolescentAdultAgedAged, 80 and overAutoantigensCell Adhesion MoleculesChildCytokinesFemaleHumansMaleMiddle AgedNerve Growth FactorsPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingYoung AdultAutoantibodiesAutoantigensCell Adhesion MoleculesCytokinesNerve Growth FactorsNFASC protein, human

Identifiers

PMID31657126
PMCPMC6856599
OpenAlexW2982500734

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.