Evidence map›Paper›PMID 31656981›Full record

ArticleJournal of molecular modeling2019

Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations.

Victor T Sabe, Gideon F Tolufashe, Collins U Ibeji, Sibusiso B Maseko, Thavendran Govender, Glenn E M Maguire, Gyanu Lamichhane, Bahareh Honarparvar, Hendrik G Kruger

Abstract read
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Article in Journal of molecular modeling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Microorganisms · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Microorganisms · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victor T SabeCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Gideon F TolufasheCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Collins U IbejiCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Sibusiso B MasekoCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Thavendran GovenderCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Glenn E M MaguireCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa.
Gyanu LamichhaneCenter for Tuberculosis Research, Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Bahareh HonarparvarCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa. Honarparvarb@ukzn.ac.za.
Hendrik G KrugerCatalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa. kruger@ukzn.ac.za.ORCID http://orcid.org/0000-0003-0606-2053

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virtual screening is a useful in silico approach to identify potential leads against various targets. It is known that carbapenems (doripenem and faropenem) do not show any reasonable inhibitory activities against L,D-transpeptidase 5 (Ldt

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsEnzyme InhibitorsLigandsMeropenemMolecular Docking SimulationMolecular Dynamics SimulationMycobacterium tuberculosisPeptidyl TransferasesProtein BindingAnti-Bacterial AgentsAntitubercular AgentsEnzyme InhibitorsLigandsMeropenemPeptidyl TransferasesL,D-transpeptidase 5 (LdtMt5)Molecular dynamics (MD)Molecular mechanics/generalized born surface area (MM-GBSA)Mycobacterium tuberculosis (M.tb)Virtual screening

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.