Evidence map›Paper›PMID 31656971›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

IGF-1 is associated with estimated bone strength in anorexia nervosa.

P K Fazeli, A T Faje, E Meenaghan, S T Russell, M Resulaj, H Lee, C J Rosen, M L Bouxsein, A Klibanski

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PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Bone, fat, and muscle interactions in health and disease.Archives of endocrinology and metabolism · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

P K FazeliNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA. pkfazeli@pitt.edu.ORCID http://orcid.org/0000-0003-1731-2927
A T FajeNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
E MeenaghanNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
S T RussellNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
M ResulajNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
H LeeHarvard Medical School, Boston, MA, USA.
C J RosenMaine Medical Center Research Institute, Scarborough, ME, USA.
M L BouxseinHarvard Medical School, Boston, MA, USA.
A KlibanskiNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USBeth Israel Deaconess Medical Center · USMaine Medical Center · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI CLIFFORD JAMES ROSEN, Gary S. Stein · 2017 to 2026
$51.6M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Interdisciplinary study of marrow adiposity, mineral metabolism,and energy balancR24DK084970 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, KLIBANSKI, ANNE · 2010 to 2010
$501k
NCATS NIH HHS UL1 1TR002541NCATS NIH HHS UL1 TR002541NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R24 DK084970NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

IGF-1 and leptin are two nutritionally dependent hormones associated with low bone mass in women with anorexia nervosa. Using finite element analysis, we estimated bone strength in women with anorexia nervosa and found that IGF-1 but not leptin correlated significantly with estimated bone strength in both the radius and tibia. PURPOSE: Women with anorexia nervosa, a psychiatric disorder characterized by self-induced starvation and low body weight, have impaired bone formation, low bone mass, and an increased risk of fracture. IGF-1 and leptin are two nutritionally dependent hormones that have been associated with low bone mass in women with anorexia nervosa. We hypothesized that IGF-1 and leptin would also be positively associated with estimated bone strength in women with anorexia nervosa.

methodsIn this cross-sectional study of 38 women (19 with anorexia nervosa and 19 normal-weight controls), we measured serum IGF-1 and leptin and performed finite element analysis of high-resolution peripheral quantitative CT images to measure stiffness and failure load of the distal radius and tibia.

resultsIGF-1 was strongly correlated with estimated bone strength in the radius (R = 0.52, p = 0.02 for both stiffness and failure load) and tibia (R = 0.55, p = 0.01 for stiffness and R = 0.58, p = 0.01 for failure load) in the women with anorexia nervosa but not in normal-weight controls. In contrast, leptin was not associated with estimated bone strength in the group of women with anorexia nervosa or normal-weight controls.

conclusionsIGF-1 is strongly associated with estimated bone strength in the radius and tibia in women with anorexia nervosa. Further studies are needed to assess whether treatment with recombinant human IGF-1 will further improve bone strength and reduce fracture risk in this population.

Indexed as

Anorexia NervosaBone DensityInsulin-Like Growth Factor IBone and BonesCross-Sectional StudiesFemaleFinite Element AnalysisHumansInsulin-Like Growth Factor IAnorexia nervosaFinite element analysisIGF-1Leptin

Identifiers

PMID31656971
PMCPMC7012750
OpenAlexW2981346020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.