Evidence map›Paper›PMID 31656692›Full record

ArticleBioResearch open access2019

The Cytotoxic Effects of Geranylgeranylacetone Are Attenuated in the High-Glucose Condition.

Yuko Nakano, Daisuke Kobayashi, Masao Miyake, Ryoko Kanno, Masahiro Murakawa, Akihiro Hazama

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioResearch open access, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuko NakanoDepartment of Anesthesiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Daisuke KobayashiDepartment of Cellular and Integrative Physiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Masao MiyakeDepartment of Cellular and Integrative Physiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Ryoko KannoDepartment of Anesthesiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Masahiro MurakawaDepartment of Anesthesiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Akihiro HazamaDepartment of Cellular and Integrative Physiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Fukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Geranylgeranylacetone (GGA) has been used as an antiulcer drug and also is known as inducer of heat shock protein 70 that has cytoprotective effects especially in hyperglycemic condition. In contrast, cytotoxicity of GGA has also been reported. Some studies have reported that GGA suppresses cell growth and induces apoptosis in cell models of human leukemia, ovarian carcinoma, and colon cancer

Indexed as

Caco-2cytotoxicitygeranylgeranylacetoneHEK293HeLa

Identifiers

PMID31656692
PMCPMC6814082
OpenAlexW2982247520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.