ArticleClaustrum2018
WFA-labeled Perineuronal Nets in the Macaque Claustrum.
Article in Claustrum, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Article
- Morphological and Molecular Characteristics of Perineuronal Nets in the Human Prefrontal Cortex-A Possible Link to Microcircuitry Specialization.Molecular neurobiology · 2025Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe claustrum (CLA) has been discussed as central to integrated conscious percepts, although recent evidence has emphasized a role in detecting sensory novelty or in amplifying correlated cortical inputs.
objectiveWe report that many neurons in the macaque CLA are ensheathed in perineuronal nets (PNNs), which contribute to synaptic stability and enhance neuronal excitability, among other properties.
designWe visualized PNNs by wisteria floribunda agglutinin (WFA) immunohistochemistry, and quantified these in comparison these to parvalbumin+ (PV) subsets and total neurons.
resultsPNNs ensheath about 11% of the total neurons. These are a range of large, medium, and small neurons, likely corresponding to PV+ and/or other inhibitory interneurons. The PNNs were themselves heterogeneous, consisting of lattice-like, weakly labeled, and diffuse subtypes, and showed some regional preference for the medial CLA.
conclusionThe abundant neuronal labeling by PNNs in the CLA suggests an important and nuanced role for inhibition, consistent with recent physiological studies of claustrocortical circuitry. For comparison, diversified inhibition in the reticular nucleus of the thalamus (a pan-inhibitory nucleus, with extensive cortical input) exerts a spectrum of control at different local and global spatiotemporal scales. Further investigation of PNN+ neurons in the macaque CLA offers a potentially important new approach to CLA function, relevant to the human brain both in normal and diseased conditions.
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