Evidence map›Paper›PMID 31656553›Full record

ArticleNano research2018

Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs.

Zhiyuan Fan, Peter Y Li, Junjie Deng, Stephen C Bady, Hao Cheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 92 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhiyuan Fan *Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Peter Y Li *Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Junjie DengDepartment of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Stephen C BadyDepartment of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Hao ChengDepartment of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA.
Drexel University · US

Funding

Injectable Biomaterial Scaffold for Inducing Antigen-Specific ToleranceR21AI133372 · NIAID · DREXEL UNIVERSITY · PI BLANKENHORN, ELIZABETH P, CHENG, HAO · 2017 to 2018
$430k
NIAID NIH HHS R21 AI133372
6 · The paper itself

Abstract

The controlled release of therapeutics from micro or nanoparticles has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may induce inflammatory and foreign body responses to scaffold constructs, limiting their applications. Here we show that widely used poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) formed by double emulsion dramatically increased neutrophil infiltration and pro-inflammatory cytokines in alginate scaffolds 1 day after the subcutaneous injection of the scaffolds into mice. The coating of red blood cell (RBC) membranes on PLGA NPs completely eliminated these short-term inflammatory responses. For a longer term of 10 days, neither PLGA NPs nor RBC membrane-coated nanoparticles exerted a significant effect on the infiltration of neutrophils or macrophages in alginate scaffolds possibly due to the degradation and/or clearance of nanoparticles by infiltrating cells by that time. Despite the extensive exploration of cell membrane-coated nanoparticles, our study is the first to investigate the effects of cell membrane coating on foreign body reaction to nanoparticles. Harnessing the natural biocompatibility of cell membranes, our strategy of anti-inflammatory protection for scaffolds may be pivotal for many applications, such as those relying on the recruitment of stem cells and/or progenitor cells to scaffolds.

Indexed as

drug deliveryendothelial cellsimmune toleranceRegenerative medicinewound healing

Identifiers

PMID31656553
PMCPMC6814018
OpenAlexW2803068216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.