SynthesisAfrican health sciences2019
Modifiable and non-modifiable risk factors in ischemic stroke: a meta-analysis.
Synthesis in African health sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Association between SARS-CoV-2 and stroke: perspectives from a metaumbrella-review.BMC neurology · 2025Pooled it
- A novel nomogram to predict mortality in patients with stroke: a survival analysis based on the MIMIC-III clinical database.BMC medical informatics and decision making · 2022Trial
- NET-mediated immunothrombosis in ischemic stroke: pathobiology, biomarkers, and therapeutic targeting.Thrombosis journal · 2026Review
- Article
- Metabolic signatures and diagnostic models of ischemic stroke and its hypertensive subtype: a non-targeted metabolomics and machine learning.Frontiers in genetics · 2026Article
- Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients.World journal of clinical cases · 2025Article
- The impact of cardiac rehabilitation program on work ability in patients following percutaneous coronary intervention (PCI): A retrospective cohort study.ARYA atherosclerosis · 2025Article
- Investigation of Lipid Profile in Patients with Cerebrovascular Diseases: Systematic Review and Meta-Analysis.Advanced biomedical research · 2025Review
- Transcriptome Sequencing-Based Screening of Key Melatonin-Related Genes in Ischemic Stroke.International journal of molecular sciences · 2024Article
- Association of triglyceride glucose index with clinical outcomes in ischemic stroke: a retrospective study.BMC neurology · 2024Observational
- Unveiling the role of HIST2H2AC in stroke through single-cell and transcriptome analysis.Functional & integrative genomics · 2024Article
- Identification and characterization of extrachromosomal circular DNA in large-artery atherosclerotic stroke.Journal of cellular and molecular medicine · 2024Article
- Association between HDL levels and stroke outcomes in the Arab population.Scientific reports · 2024Article
- Comparison of performances of SIREN or MFSRS in stroke risk prediction in an African environment.BMC public health · 2024Article
- Evaluating the Causal Effects of Low Density Lipoprotein Cholesterol Levels on Ischemic Stroke: A Mendelian Randomization Study.Iranian journal of public health · 2024Article
- The Role of Modifying Risk Factors as Well as Body Mass Index, Waist Circumference and Hip to Waist Ratio as Anthropometric Indicators and Parameters of Obesity in the Occurence of Stroke.Materia socio-medica · 2024Article
- Spatial analysis of ischemic stroke in Spain: the roles of accessibility to healthcare and economic development.Cadernos de saude publica · 2024Article
- Hemodynamic alterations and their clinical implications in the vertebrobasilar system among patients with isolated posterior circulation ischemic vertigo.Frontiers in neurology · 2024Article
- Population-based stroke risk profile from a West-African community.eNeurologicalSci · 2023Article
- Medical Management of Dyslipidemia for Secondary Stroke Prevention: Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is a heterogeneous, multifactorial disease regulated by modifiable and non-modifiable risk factors like total cholesterol, triglycerides, high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C) and glucose and non-modifiable factors like age. Evaluation of these risk factors for ischemic stroke may contribute to more effective prevention.
methodsThis meta-analysis investigated the data up to 2018 with respect to age, total cholesterol, triglycerides, high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C) and glucose levels in the Ischemic stroke patients and controls. Data from each eligible study was extracted such as year of publication, first author name, ethnicity/country, number of ischemic stroke patients and healthy controls and studies were subjected to heterogeneity analysis.
resultsMeta-analysis of the modifiable and non-modifiable risk factors like total cholesterol, HDL-C and LDL-C glucose, triglycerides levels and age were not having significantly associated with ischemic stroke (p>0.05). However meta-analysis of triglyceride yielded significant association ischemic stroke with overall 95% CI (-0.62- (-0.09) and P= 0.007 and glucose also showed significant association with ischemic stroke with 95% CI (-1.08- (-0.14), P=0.01. Studies were subjected to heterogeneity which revealed significant heterogeneity with (P<0.00) and I2>96%.
conclusionMeta-analysis revealed that levels of triglyceride and glucose are the predisposing factors for ischemic stroke in the Asian population.
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