Evidence map›Paper›PMID 31656464›Full record

ArticleAfrican health sciences2019

Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa.

Muhammed Ogunlola, Poovendhree Reddy, Maureen N Sibiya, Laura O'Connor, Dorinda Borg, Firoza Haffejee, Shanaz Ghuman, Thembelihle Ngxongo, Nalini Govender

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Muhammed OgunlolaDepartment of Community Health Studies, Faculty of Health Sciences, Durban University of Technology.
Poovendhree ReddyDepartment of Community Health Studies, Faculty of Health Sciences, Durban University of Technology.
Maureen N SibiyaFaculty of Health Sciences, Durban University of Technology, Durban, South Africa.
Laura O'ConnorDepartment of Chiropractic and Somatology, Faculty of Health Sciences, Durban University of Technology, SA.
Dorinda BorgDepartment of Chiropractic and Somatology, Faculty of Health Sciences, Durban University of Technology, SA.
Firoza HaffejeeDepartment of Basic Medical Sciences, Durban University of Technology, Durban, South Africa.
Shanaz GhumanDepartment of Community Health Studies, Faculty of Health Sciences, Durban University of Technology.
Thembelihle NgxongoDepartment of Nursing, Faculty of Health Sciences, Durban University of Technology, SA.
Nalini GovenderDepartment of Basic Medical Sciences, Durban University of Technology, Durban, South Africa.
Durban University of Technology · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBased on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women.

objectiveTo determine the angiogenic profiles throughout uncomplicated pregnancies in HIV positive and HIV negative women. We explored possible correlations between angiogenic serum levels and selected maternal characteristics (HIV status, gestational age, maternal factors, and pregnancy outcomes).

methodThis study was conducted at a primary health care facility in Durban, South Africa. Forty-six pregnant women aged 18-45 years, were enrolled at 10-20, 22-30 and 32-38 weeks' gestation, respectively through convenient sampling. Serum samples were collected and quantitatively evaluated using ELISAs. Clinical and epidemiological data were analysed using STATA (version 14). A probability level of p < 0.05 was considered statistically significant.

resultsOf those enrolled, 28.3% were nulliparous, 82% were HIV positive and none developed pre-eclampsia. Systolic and diastolic blood pressure increased slightly throughout pregnancy. Fluctuating angiogenic and anti-angiogenic levels were demonstrated during pregnancy.

conclusionThis study contributes to the current angiogenic knowledge in normotensive pregnancies, and may assist as a reference range against which these factors may be compared in HIV complicated pregnancies.

Indexed as

AdolescentAdultBiomarkersBlood PressureCase-Control StudiesEndoglinFemaleGestational AgeHIV InfectionsHumansMiddle AgedPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy ProteinsVascular Endothelial Growth Factor Receptor-1BiomarkersEndoglinFLT1 protein, humanPregnancy ProteinsVascular Endothelial Growth Factor Receptor-1HIVPlGFpregnancysEngsFlt-1

Identifiers

PMID31656464
PMCPMC6794537
OpenAlexW2969792308

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.