Evidence map›Paper›PMID 31656107›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4-

Yuanying Fang, Shaokun Zhang, Min Li, Lijuan Xiong, Liangxing Tu, Saisai Xie, Yi Jin, Yanhua Liu, Zunhua Yang, Ronghua Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuanying FangCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Shaokun ZhangNational Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Min LiCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Lijuan XiongCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Liangxing TuNational Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Saisai XieNational Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Yi JinNational Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Yanhua LiuCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Zunhua YangCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.
Ronghua LiuCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine , Nanchang , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPR119 is a promising target for discovery of anti-type 2 diabetes mellitus agents. We described the optimisation of a novel series of pyrimido[5,4-

Indexed as

AnimalsBlood GlucoseDose-Response Relationship, DrugGlucose Tolerance TestHumansHypoglycemic AgentsMiceMice, Inbred C57BLMolecular StructureOxazinesPyrimidinesReceptors, G-Protein-CoupledStructure-Activity RelationshipBlood GlucoseGPR119 protein, humanHypoglycemic AgentsOxazinesPyrimidinesReceptors, G-Protein-CoupledGPR 119 agonistsOptimisationpyrimidodihydrooxazinetype 2 diabetes mellitus

Identifiers

PMID31656107
PMCPMC6830257

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.