ArticleAging clinical and experimental research2020
Characterization of the gut microbiota in frail elderly patients.
Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty.Brain and behavior · 2025Pooled it
- Gut microbiome and frailty: insight from genetic correlation and mendelian randomization.Gut microbes · 2023Pooled it
- Effectiveness of Multistrain Probiotic Formulation on Common Infectious Disease Symptoms and Gut Microbiota Modulation in Flu-Vaccinated Healthy Elderly Subjects.BioMed research international · 2022Trial
- Gut microbiota characteristics in patients with inguinal hernia: a prospective observational study.Hernia : the journal of hernias and abdominal wall surgery · 2026Observational
- Taxonomic and functional remodeling of the gut microbiota during aging and implications for microbiota-derived biomarkers.World journal of microbiology & biotechnology · 2026Review
- The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty.Frontiers in cellular and infection microbiology · 2026Review
- Analysis of alterations in the composition of the intestinal microbiota in frail older individuals.PloS one · 2025Article
- Low skeletal muscle density is a risk factor for constipation in patients on maintenance dialysis.Frontiers in physiology · 2025Article
- Integrating sarcopenia and non-contrast CT radiomics for preoperative prediction of survival in sarcomatoid renal cell carcinoma.Frontiers in oncology · 2025Article
- Rsearch progress on the relationship between aging and microbiota in sarcopenia.Frontiers in medicine · 2025Review
- Correlation between the gut microbiota composition and cognitive frailty: a case-control study in community-dwelling older adults.Frontiers in nutrition · 2025Article
- Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies.World journal of clinical cases · 2024Article
- Clinical Phenotypes Associated with the Gut Microbiome in Older Japanese People with Care Needs in a Nursing Home.Nutrients · 2024Observational
- Causal Relationship Between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Review
- Oral microbial signatures associated with age and frailty in Canadian adults.Scientific reports · 2024Article
- Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.Scientific reports · 2024Article
- Exploring Causal Links Between Gut Microbiota and Geriatric Syndromes: A Two-Sample Mendelian Randomization Analysis.International journal of medical sciences · 2024Article
- Gut-muscle axis mechanism of exercise prevention of sarcopenia.Frontiers in nutrition · 2024Review
- Progress of linking gut microbiota and musculoskeletal health: casualty, mechanisms, and translational values.Gut microbes · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe change in the composition of gut microbiota has been reported in the elderly and in the frail individuals; however, studies on gut microbiota in frail elderly are limited.
aimsThis study aimed to investigate the gut microbiota of the frail elderly.
methodsFrom September 2017 to February 2018, 27 elderly patients hospitalized in the Department of Geriatrics of our hospital were enrolled and divided into the frailty group (n = 15) and the control group (n = 12) based on the cutoff of 0.25 for the frailty index. The fecal samples were collected for 16S rRNA-amplicon sequencing to analyze the composition and richness of gut microbiota. Operational taxonomic unit (OTU) clustering was performed using Usearch software. Intra-sample diversity (alpha-diversity) analysis and inter-sample diversity (beta-diversity) analyses were performed. The community richness was compared between the two groups at family and genus levels.
resultsThere were 1903 and 1880 OTUs identified in the control and frailty groups, respectively, with 1282 OTUs overlap between the two groups. The alpha diversity of microbiota community was similar between the two groups, whereas the frailty group had larger beta diversity than the control group. The top-10 taxonomy categories and abundances of gut microbiota between the two groups were similar. As for the gut microbiota composition, 4 families and 17 genera were significantly different between the two groups (p < 0.05).
conclusionThese results suggested that frailty can affect gut microbiota diversity and compositions in late elderly hospitalized patients.
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