Evidence map›Paper›PMID 31655945›Full record

ArticleEuropean journal of epidemiology2019

Effect heterogeneity and variable selection for standardizing causal effects to a target population.

Anders Huitfeldt, Sonja A Swanson, Mats J Stensrud, Etsuji Suzuki

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  6. Causal Inference Methods for Combining Randomized Trials and Observational Studies: A Review.Statistical science : a review journal of the Institute of Mathematical Statistics · 2024
    Article
  7. Article
  8. Review
  9. A directed acyclic graph for interactions.International journal of epidemiology · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 4 countries.

Anders HuitfeldtNorwegian Institute of Public Health, Oslo, Norway. anders@huitfeldt.net.ORCID http://orcid.org/0000-0002-0904-4945
Sonja A SwansonDepartment of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
Mats J StensrudDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
Etsuji SuzukiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
Harvard University · USNorwegian Institute of Public Health · NO

Funding

Japan Society for the Promotion of Science JP15K08776Japan Society for the Promotion of Science JP17K17898Japan Society for the Promotion of Science JP18K1010Norges Forskningsråd NFR239956/F2NWO/ZonMw Veni 9161706
6 · The paper itself

Abstract

The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing results to a target population. We discuss several different types of homogeneity conditions that are relevant for standardization: Homogeneity of effect measures, homogeneity of counterfactual outcome state transition parameters, and homogeneity of counterfactual distributions. Each of these conditions can be used to show that a particular standardization procedure will result in an unbiased estimate of the effect in the target population, given assumptions about the relevant scientific context. We compare and contrast the homogeneity conditions, in particular their implications for selection of covariates for standardization and their implications for how to compute the standardized causal effect in the target population. While some of the recently developed counterfactual approaches to generalizability rely upon homogeneity conditions that avoid many of the problems associated with traditional approaches, they often require adjustment for a large (and possibly unfeasible) set of covariates.

Indexed as

Health Services Needs and DemandModels, StatisticalRandomized Controlled Trials as TopicReference StandardsHumansModels, TheoreticalPatient SelectionEffect heterogeneityEffect measuresExternal validityGeneralizabilityMethodologyStandardization

Identifiers

PMID31655945
OpenAlexW2946118395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.