Evidence map›Paper›PMID 31655855›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Effects of the solid lipid nanoparticle of carvacrol on rodents with lung injury from smoke inhalation.

Fernanda O Carvalho, Érika R Silva, Paula S Nunes, Fernanda A Felipe, Karen P P Ramos, Luiz Augusto S Ferreira, Viviane N B Lima, Saravanan Shanmugam, Alan Santos Oliveira, Sílvia S Guterres and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Targeting respiratory virus-induced reactive oxygen species in airways diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. 3D Printed SiOJournal of medicinal chemistry · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Fernanda O CarvalhoHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Érika R SilvaHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Paula S NunesHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil. paulanunes_se@yahoo.com.br.
Fernanda A FelipeHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Karen P P RamosHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Luiz Augusto S FerreiraHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Viviane N B LimaHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Saravanan ShanmugamHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil. saranflora04@gmail.com.
Alan Santos OliveiraHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Sílvia S GuterresPost-Graduation Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Ipiranga Avenue 2752, Porto Alegre, RS, 90610-000, Brazil.
Enilton A CamargoHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Tassia Virginia Cravalho OliveraInstitute of Technology and Research, Tiradentes University, Murilo Dantas Avenue 300, Aracaju, SE, 49032-490, Brazil.
Ricardo Luiz C de Albuquerque JúniorInstitute of Technology and Research, Tiradentes University, Murilo Dantas Avenue 300, Aracaju, SE, 49032-490, Brazil.
Waldecy de Lucca JuniorHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Lucindo José Quintans-JúniorHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Adriano A S AraújoHealth Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, Aracaju, SE, 49060-100, Brazil.
Universidade Federal de Sergipe · BRUniversidade Tiradentes · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this present study was to evaluate the effect of solid lipid nanoparticles (SLN) containing carvacrol over the lung damage of airway smoke inhalation. The study was conducted with 30 rats subjected to smoke inhalation and divided into 5 groups such as, normal control, negative control, oxygen group, SLN alone, and SLN+CARV group. The animals were sacrificed 24 h after the induction of inhalation injury further, the tissues of larynx, trachea, and lungs were collected for the histological, hematological, myeloperoxidase, and malondialdehyde analysis. The obtained results showed that treatment with CARV+SLN minimized the inhalation injury, since it reduced malondialdehyde significantly, when compared to the negative control group and minimized the histological changes which proves the absence of pulmonary emphysema and exudate in laryngeal and tracheal lumen in the CARV+SLN-treated group. Meanwhile, the presence of lesion with chronic characteristics was observed in the negative control and oxygen groups. It is suggested that the SLN containing carvacrol minimized oxidative stress and histological damages generated from smoke inhalation in rodents.

Indexed as

Administration, InhalationAnimalsCymenesDrug CarriersFemaleLipidsLung InjuryNanoparticlesOxidative StressRandom AllocationRatsRats, WistarSmoke Inhalation InjurycarvacrolCymenesDrug CarriersLipidsCarvacrolInhalationLung injuryNatural productSmokeSolid lipid nanoparticle

Identifiers

PMID31655855
OpenAlexW2981946651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.