Evidence map›Paper›PMID 31655832›Full record

SynthesisMedicina oral, patologia oral y cirugia bucal2020

Alcohol-based mouthwash as a risk factor of oral cancer: A systematic review.

M Ustrell-Borràs, B Traboulsi-Garet, C Gay-Escoda

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Medicina oral, patologia oral y cirugia bucal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  8. Review
  9. Review
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  15. Article
  16. Review
  17. A Fresh Look at Mouthwashes-What Is Inside and What Is It For?International journal of environmental research and public health · 2022
    Article
  18. Article
  19. Review
  20. Transcriptomic Profile Analysis ofEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Ustrell-BorràsFaculty of Medicine and Health Sciences, Oral Surgery and Implantology University of Barcelona, Campus de Bellvitge C/FeixaLlarg, s/n, Pavelló Govern, 2da Planta 08907 L'Hospitalet de Llobregat, Barcelona, Spain basselt.121@gmail.com.
B Traboulsi-Garet
C Gay-Escoda

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral and pharynx cancer represent a serious global problem, reaching an incidence of half a million cases annually. The role of tobacco and alcohol have been studied and proven to be one of its risk factors. We also know that mouthwashes contain a variable percentage of alcohol, so there is a reasonable concern about their role in carcinogenesis. MATERIALS AND

methodsTo answer the PICOS (Population; Intervention; Comparison; Outcomes; Study) question: Do patients (Population) who use alcohol-based mouthwashes (Intervention) compared to those who do not use them (Comparison) have higher acetaldehyde levels in saliva or higher risk of oral cancer development? (Outcomes) Meta-analyses, systematic reviews, randomized and non-randomized clinical trials, case-control studies, and prospective and retrospective cohort studies were included (Study). Two independent authors conducted literature screening through MEDLINE, Scopus and the Cochrane Library, and they also conducted article and data extraction to undertake quality analyses. The main outcome measures were salivary acetaldehyde levels or the risk of oral cancer development. The most relevant data was extracted and the risk of bias from the studies included was also evaluated.

resultsOut of 497 potentially eligible papers, 8 studies were included in the qualitative analysis which include a total of 43,499 subjects: two meta-analyses, a clinical trial, three case-control studies and two cohort studies. One study (n = 3,926) found a relationship between alcohol mouthwash and oral cancer, two studies (n = 25,033) found this relationship when a high frequency of mouthwash was present, three studies (n = 14,482) failed to find this relationship and 2 studies (n = 58) found a temporary increase of acetaldehyde levels in saliva after alcohol mouthwash.

conclusionsIt cannot be guaranteed that the use of mouthwash represents an independent risk factor for the development of head and neck cancer. However, the risk does increase when it occurs in association with other carcinogenic risk factors.

Indexed as

Mouth NeoplasmsMouthwashesHumansProspective StudiesRetrospective StudiesRisk FactorsMouthwashes

Identifiers

PMID31655832
PMCPMC6982979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.