Evidence map›Paper›PMID 31655798›Full record

ArticleAging2019

T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma.

Sheng Zhong, Bo Wu, Jiahui Li, Xinhui Wang, Shanshan Jiang, Fangfei Hu, Gaojing Dou, Yuan Zhang, Chunjia Sheng, Gang Zhao and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Jun, an Oncological Foe or Friend?International journal of molecular sciences · 2025
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  8. Selective antagonism of cJun for cancer therapy.Journal of experimental & clinical cancer research : CR · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sheng ZhongDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
Bo WuClinical College, Jilin University, Changchun, China.
Jiahui LiPharmacy College, Jilin University, Chuangchun, China.
Xinhui WangClinical College, Jilin University, Changchun, China.
Shanshan JiangPharmacy College, Jilin University, Chuangchun, China.
Fangfei HuPharmacy College, Jilin University, Chuangchun, China.
Gaojing DouClinical College, Jilin University, Changchun, China.
Yuan ZhangClinical College, Jilin University, Changchun, China.
Chunjia ShengClinical College, Jilin University, Changchun, China.
Gang ZhaoDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
Yunqian LiDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
Yong ChenDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We tested whether the drugs T5224, RSPO2, and AZD5363 exert therapeutic effects against functioning pituitary adenoma (FPA). We analysed the gene expression profiles of four FPA mRNA microarray datasets (GSE2175, GSE26966, GSE36314, and GSE37153) from the Gene Expression Omnibus database and identified genes differentially expressed in FPA vs control tissues. We then carried out Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction network analyses. We also measured the difference in expression of hub genes between human normal pituitary cells and FPA cells using qRT-PCR. Our

Indexed as

Antineoplastic AgentsBenzophenonesCell LineGene Expression RegulationGene Regulatory NetworksHumansIsoxazolesOligonucleotide Array Sequence AnalysisPituitary GlandPituitary NeoplasmsPyrimidinesPyrroles3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acidAntineoplastic AgentsBenzophenonescapivasertibIsoxazolesPyrimidinesPyrrolesbioinformaticsbrain sciencedrug treatmentfunctional pituitary adenomasprognosis

Identifiers

PMID31655798
PMCPMC6834428
OpenAlexW2981639570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.