ArticleRadiation oncology (London, England)2019
Feasibility and preliminary clinical results of linac-based Stereotactic Body Radiotherapy for spinal metastases using a dedicated contouring and planning system.
Article in Radiation oncology (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Global research trends in radiotherapy for bone metastases: a systematic bibliometric analysis.Frontiers in oncology · 2025Pooled it
- Commissioning and validation of a Monte Carlo algorithm for spine stereotactic radiosurgery.Journal of applied clinical medical physics · 2023Article
- The impact of radiosensitivity on clinical outcomes of spinal metastases treated with stereotactic body radiotherapy.Cancer medicine · 2023Article
- Stereotactic body radiotherapy for spinal metastases: a review.Medical oncology (Northwood, London, England) · 2022Review
- Clinical Evaluation of an Auto-Segmentation Tool for Spine SBRT Treatment.Frontiers in oncology · 2022Article
- Evaluation of a Dedicated Software "Elements™ Spine SRS, BrainlabFrontiers in oncology · 2022Article
- Interstitial High-Dose-Rate Brachytherapy of Liver Metastases in Oligometastatic Patients.Cancers · 2021Article
- Reduction of inter-observer differences in the delineation of the target in spinal metastases SBRT using an automatic contouring dedicated system.Radiation oncology (London, England) · 2021Article
- Method of computing direction-dependent margins for the development of consensus contouring guidelines.Radiation oncology (London, England) · 2021Article
- X-change symposium: status and future of modern radiation oncology-from technology to biology.Radiation oncology (London, England) · 2021Review
- Delayed postoperative radiotherapy increases the incidence of radiographic local tumor progression before radiotherapy and leads to poor prognosis in spinal metastases.Radiation oncology (London, England) · 2021Article
- Outcome and toxicity of hypofractionated image-guided SABR for spinal oligometastases.Clinical and translational radiation oncology · 2020Article
- Precision Stereotactic Radiotherapy for Spinal Tumors: Mechanism, Efficacy, and Issues.Frontiers in oncology · 2020Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) are well established local treatment approaches in several cancer settings. Although SBRT is still under investigation for spinal metastases, promising results in terms of a high effectiveness and optimal tolerability have been recently published on this topic. For spinal SBRT, one of the most relevant issues is represented by the inter-observer variability in target definition. Recently, several technological innovations, including specific tools such as multimodality-imaging (computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography (PET-CT), automated volumes contouring and planning, could allow clinicians to minimize the uncertainties related to spinal SBRT workflow. Aim of this study is to report the feasibility of the clinical application of a dedicated software (Element®, Brainlab™ Germany) for spinal metastases SBRT. MATERIAL AND
methodThe patient selection criteria for SBRT in spinal metastases were the following: age > 18 years, diagnosis of spinal metastases (n ≤ 3), life expectancy > 3 months, controlled primary tumor or synchronous diagnosis and Spinal Instability Neoplastic Score (SINS) ≤ 12 points. All radiation target volumes were defined and planned with the support of the dedicated software Elements® (Brainlab™ Germany). Different dose prescription have been used: 12 Gy in single fraction, 12 Gy, 18 Gy, 21 Gy and 24 Gy in 3 fractions. Toxicity was assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. SPSS version 20 was used for statistical analysis.
resultsFrom April 2018 to April 2019, 54 spinal metastases in 32 recruited patients were treated with Linac-based SBRT. With a median follow-up of 6 months (range 3-12), local control rates at 6 months and 9 months were 86 and 86%, respectively. No adverse events ≥3 grade were observed.
conclusionsThis preliminary experience shows that with respect to acute toxicity and early clinical response, linac-based using Elements® Spine SRS is a feasible and effective approach.
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