ArticleBMC psychiatry2019
Association between benzodiazepines and suicide risk: a matched case-control study.
Article in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Prescribed benzodiazepines and suicidal behaviors: a systematic review, meta-analysis, and clinical implications.BMC psychiatry · 2026Pooled it
- Anxiety Screening: Evidence Report and Systematic Review for the US Preventive Services Task Force.JAMA · 2023Pooled it
- Multicenter toxicological analysis of psychoactive substances in suicide victims in Brazil.Forensic science, medicine, and pathology · 2026Article
- Initiation of High-Potency Benzodiazepine Prescriptions Among Survivors of Severe Trauma.Acta anaesthesiologica Scandinavica · 2026Article
- Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies.EClinicalMedicine · 2026Article
- Off-Label Prescription of Benzodiazepines: A Retrospective Cohort Study of Prescribing Prevalence in Primary Care.Clinical drug investigation · 2025Article
- Suicidal Ideation and Suicide Completion in Benzodiazepine Users: A Systematic Review of Current Evidence.Cureus · 2025Review
- Article
- Molecular Aspects of the Interactions between Selected Benzodiazepines and Common Adulterants/Diluents: Forensic Application of Theoretical Chemistry Methods.International journal of molecular sciences · 2024Article
- Prescribing and deprescribing guidance for benzodiazepine and benzodiazepine receptor agonist use in adults with depression, anxiety, and insomnia: an international scoping review.EClinicalMedicine · 2024Article
- Suicide deaths and substance use in Spain between 2010 and 2022.Frontiers in psychiatry · 2024Article
- Risk factors for suicide among veterans living with and without HIV: a nested case-control study.AIDS and behavior · 2024Article
- Drug Safety and Suicidality Risk of Chronic Pain Medications.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Fell on Black Days: Analyzing the Song Lyrics of Chris Cornell for Insight into Depression and Suicide.International journal of environmental research and public health · 2023Article
- Association rule mining of real-world data: Uncovering links between race, glycemic control, lipid profiles, and suicide attempts in individuals with diabetes.Informatics in medicine unlocked · 2023Article
- Twenty-year medication use trends in first-episode bipolar disorder.Acta psychiatrica Scandinavica · 2022Article
- Associations between treatment with melatonin and suicidal behavior: a nationwide cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Implementing an Online Program to Change Benzodiazepine Prescription: Protocol of a Hybrid Type 1 Cluster-Randomised Trial.Portuguese journal of public health · 2022Article
- Suicidal ideation in patients with mental illness and concurrent substance use: analyses of national census data in Norway.BMC psychiatry · 2022Article
- Co-prescribing of opioids and benzodiazepines/Z-drugs associated with all-cause mortality-A population-based longitudinal study in primary care with weak opioids most commonly prescribed.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is unclear whether benzodiazepines increase the risk of suicide. The aim of this study was to test the hypothesis that benzodiazepines are associated with an increased risk of suicide, by comparing psychopharmacological interventions between psychiatric patients who committed suicide and a group of matched controls.
methodsThe case group comprised 154 psychiatric patients (101 men, 53 women; age range: 13-96 years) who had committed suicide in Örebro County, Sweden. Control psychiatric patients matched by age, sex, and main psychiatric diagnosis were selected for each case. Binary logistic regression was used to calculate odds ratios in unadjusted and adjusted models.
resultsBenzodiazepine prescriptions were more common among cases than controls (65/154 [42.2%] versus 43/154 [27.9%], p = 0.009, odds ratio: 1.89 [95% CI: 1.17-3.03]). This association remained significant in a model adjusted for previous suicide attempts and somatic hospitalizations (odds ratio: 1.83 [95% CI: 1.06-3.14]). No statistically significant differences were seen between the groups in the use of any other subtype of psychopharmaceutical agent.
conclusionsThese data indicate that benzodiazepine use may increase the risk of suicide. However, this study is limited by the potential for indication bias.
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