ArticleBMC plant biology2019
Tomato glycosyltransferase Twi1 plays a role in flavonoid glycosylation and defence against virus.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- VfUGT87H9 Enhances Fusarium Resistance in Vernicia fordii via Myricetin Glucosylation-Mediated Flavonoid Metabolism.Plant, cell & environment · 2026Article
- Integrative cross-study analysis of maize microarray datasets identifies key abiotic stress-responsive genes, highlighting ZmOSM34 and ZmANAH.Scientific reports · 2026Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- SaUGTs regulate YE-induced phytoalexins homeostasis in Sorbus aucuparia suspension cells.BMC plant biology · 2025Article
- Review
- Genome-Wide Analysis and Identification of UDP Glycosyltransferases Responsive to Chinese Wheat Mosaic Virus Resistance inViruses · 2024Article
- Similarities in Structure and Function of UDP-Glycosyltransferase Homologs from Human and Plants.International journal of molecular sciences · 2024Review
- Article
- Plant Secondary Metabolites: The Weapons for Biotic Stress Management.Metabolites · 2023Review
- SlS5H silencing reveals specific pathogen-triggered salicylic acid metabolism in tomato.BMC plant biology · 2022Article
- Molecular Cloning and Functional Analysis ofLife (Basel, Switzerland) · 2022Article
- Transcriptomics and Metabolomics Analyses Reveal Defensive Responses and Flavonoid Biosynthesis ofMolecules (Basel, Switzerland) · 2022Article
- Widely targeted analysis of metabolomic changes of Cucumis sativus induced by cucurbit chlorotic yellows virus.BMC plant biology · 2022Article
- Phosphorylated viral protein evades plant immunity through interfering the function of RNA-binding protein.PLoS pathogens · 2022Article
- Comparative Transcriptome Analysis of Onion in Response to Infection byFrontiers in plant science · 2022Article
- Genomic and Molecular Characterization of Wheat Streak Mosaic Virus Resistance LocusFrontiers in plant science · 2022Article
- Overexpression of Lectin Receptor-Like Kinase 1 in Tomato Confers Resistance toFrontiers in plant science · 2022Article
- Identification of α-Glucosidase Inhibitors from Leaf Extract of Pepper (Metabolites · 2021Article
- Recent progress in synthesis of carbohydrates with sugar nucleotide-dependent glycosyltransferases.Current opinion in chemical biology · 2021Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSecondary metabolites play an important role in the plant defensive response. They are produced as a defence mechanism against biotic stress by providing plants with antimicrobial and antioxidant weapons. In higher plants, the majority of secondary metabolites accumulate as glycoconjugates. Glycosylation is one of the commonest modifications of secondary metabolites, and is carried out by enzymes called glycosyltransferases.
resultsHere we provide evidence that the previously described tomato wound and pathogen-induced glycosyltransferase Twi1 displays in vitro activity toward the coumarins scopoletin, umbelliferone and esculetin, and the flavonoids quercetin and kaempferol, by uncovering a new role of this gene in plant glycosylation. To test its activity in vivo, Twi1-silenced transgenic tomato plants were generated and infected with Tomato spotted wilt virus. The Twi1-silenced plants showed a differential accumulation of Twi1 substrates and enhanced susceptibility to the virus.
conclusionsBiochemical in vitro assays and transgenic plants generation proved to be useful strategies to assign a role of tomato Twi1 in the plant defence response. Twi1 glycosyltransferase showed to regulate quercetin and kaempferol levels in tomato plants, affecting plant resistance to viral infection.
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