ArticleBMC infectious diseases2019
Case report: whole genome sequencing based investigation of maternal-neonatal listeriosis in Sichuan, China.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Neonatal Listeriosis with Central Nervous System Involvement: A Case Series and Review of the Literature.Antibiotics (Basel, Switzerland) · 2026Review
- Differential virulence gene carriage inFrontiers in microbiology · 2026Article
- Function analysis of LIPI-4 inVirulence · 2025Article
- Fulminant neonatal listeriosis with death within 24 hours in a preterm infant: a case report.BMC infectious diseases · 2025Article
- Characterization of aMicrobial genomics · 2025Article
- Maternal-Fetal Listeriosis in China: Clinical and Genomic Characteristics From an ST8Infection and drug resistance · 2025Article
- Clinical and Genomic Characteristics of a Clinical Listeria Monocytogenes ST120 Isolate Recovered from a Pregnant Woman.Infection and drug resistance · 2024Article
- Listeriosis During Pregnancy: Maternal and Neonatal Consequences-A Case Report.International journal of women's health · 2023Article
- Phenotypic, chemical component and molecular assessment of genetic diversity and population structure of Morinda officinalis germplasm.BMC genomics · 2022Article
- Dissecting Listeria monocytogenes Persistent Contamination in a Retail Market Using Whole-Genome Sequencing.Microbiology spectrum · 2022Article
- A Whole Genome Sequencing-Based Epidemiological Investigation of a Pregnancy-Related Invasive Listeriosis Case in Central Italy.Pathogens (Basel, Switzerland) · 2022Article
- Genomic Characterization of a ClinicalInfection and drug resistance · 2022Article
- Plasmidome ofInternational journal of molecular sciences · 2021Article
- Clinical and Laboratory Characteristics of Patients infected byInfection and drug resistance · 2021Article
- An Update Review on Listeria Infection in Pregnancy.Infection and drug resistance · 2021Review
- Maternal-neonatal listeriosis.Virulence · 2020Review
- 10-Year Molecular Surveillance ofFrontiers in microbiology · 2020Article
- Genomic dissection of the most prevalent Listeria monocytogenes clone, sequence type ST87, in China.BMC genomics · 2019Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNeonatal listeriosis is a rare but severe disease manifesting as septicemia and central nervous system (CNS) infections with a high fatality rate of around 20 to 30%. Whole genome sequencing (WGS) is a promising technique for pathogen identification and infection source tracing with its high resolution. CASE PRESENTATION: A case of neonatal sepsis with listeriosis was reported with positive blood culture for Listeria monocytogenes. The case was investigated to confirm the vertical transmission of the infection and identify the potential food source of the maternal L. monocytogenes infection using WGS. L. monocytogenes was isolated from the neonate's blood sample the day after caesarean delivery and from the mother's genital and pudenda swab samples 5 days and 13 days after caesarean delivery. WGS showed that the isolate from the neonate was identical to the genome type of the isolates from the mother, with only one of the 4 isolates from the mother differing by one single nucleotide polymorphism (SNP). By WGS, one L. monocytogenes isolate from a ready-to-eat (RTE) meat sample in the patients' community market shared the same sequence type but was ruled out as the cause of infection, with 57 SNP differences to the strain causing the maternal-neonatal infection. The food isolate also carried a novel plasmid pLM1686 that harbored heavy metal resistance genes. After caesarean section, the mother was treated with a third generation cephalosporin which L. monocytogenes is naturally resistant to, which may explain why genital and pudenda swabs were still culture-positive for L. monocytogenes 13 days after delivery.
conclusionsGenital swab culture for L. monocytogenes had been informative in the diagnosis of maternal listeriosis in this case. The high resolution of WGS confirmed the maternal-neonatal transmission of L. monocytogenes infection and ruled out the L. monocytogenes contaminated RTE meat from the local market as the direct source of the mother's infection.
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Registered trials
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