Evidence map›Paper›PMID 31655139›Full record

ArticleMagnetic resonance imaging2020

Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.

Ante Zhu, Scott B Reeder, Kevin M Johnson, Sydney M Nguyen, Sean B Fain, Ian M Bird, Thaddeus G Golos, Oliver Wieben, Dinesh M Shah, Diego Hernando

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. BRIDGING COTYLEDON PATHOLOGY AND PERFUSION IN HEALTHY PRIMATE PREGNANCY.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  6. Article
  7. Magnetic resonance imaging of the monkey fetal brain in utero.Investigative magnetic resonance imaging · 2022
    Article
  8. Feasibility of QSM in the human placenta.Magnetic resonance in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ante ZhuDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; Department of Radiology, University of Wisconsin, Madison, WI, USA.
Scott B ReederDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; Department of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA; Department of Medicine, University of Wisconsin, Madison, WI, USA; Department of Emergency Medicine, University of Wisconsin, Madison, WI, USA.
Kevin M JohnsonDepartment of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
Sydney M NguyenWisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA; Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA.
Sean B FainDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; Department of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
Ian M BirdDepartment of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA.
Thaddeus G GolosWisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA; Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA; Department of Comparative Biosciences, University of Wisconsin, Madison, WI, USA.
Oliver WiebenDepartment of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA.
Dinesh M ShahDepartment of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA.
Diego HernandoDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, USA; Department of Radiology, University of Wisconsin, Madison, WI, USA; Department of Medical Physics, University of Wisconsin, Madison, WI, USA; Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI, USA. Electronic address: dhernando@wisc.edu.
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Advanced MRI FOR Uteroplacental Flow, Perfusion, Oxygenation & InflammationU01HD087216 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SHAH, DINESH MANILAL, WIEBEN, OLIVER · 2015 to 2015
$4.0M
Endocrinology-Reproductive Physiology Training GrantT32HD041921 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI BIRD, IAN M. · 2004 to 2022
$3.0M
Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017
$2.7M
MRI-based Quantitative Susceptibility Mapping of Hepatic Iron OverloadR01DK117354 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2018 to 2021
$2.3M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NICHD NIH HHS T32 HD041921NICHD NIH HHS U01 HD087216NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK100651NIDDK NIH HHS R01 DK117354NIH HHS P51 OD011106
6 · The paper itself

Abstract

objectivesTo assess the feasibility of ferumoxytol-enhanced MRI in pregnancy with a nonhuman primate model. MATERIALS AND

methodsIn this prospective study, eleven pregnant rhesus macaques at day 98 ± 5 of gestation were divided into three groups, untreated control (UC) (n = 3), saline control (SC) (n = 4) and interleukin 1 beta (IL-1β) treated (IT) (n = 4), which were administered with either saline or IL-1β into the amniotic fluid. All animals were imaged at multiple time points before and after ferumoxytol administration (4 mg/kg). Longitudinal R2* and susceptibility of tissues were obtained using region-of-interest analysis and the longitudinal changes were assessed using linear mixed models and Student's t-test.

resultsIn fetuses, a slope of 0.3 s

conclusionsThis work demonstrates the feasibility of quantitative ferumoxytol-enhanced MRI to measure dynamics of ferumoxytol delivery and washout in the placenta. Stable MRI measurements indicated no evidence of iron deposition in fetal tissues of nonhuman primates after maternal ferumoxytol exposure.

Indexed as

Magnetic Resonance ImagingPregnancy, AnimalAnimalsContrast MediaFeasibility StudiesFemaleFerrosoferric OxideInflammationInterleukin-1betaIronMacaca mulattaPlacentaPregnancyProspective StudiesContrast MediaFerrosoferric OxideInterleukin-1betaIronFerumoxytolMagnetic susceptibilityPlacentaQuantitativeR2*

Identifiers

PMID31655139
PMCPMC6956847
OpenAlexW2981973866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.