ReviewCurrent opinion in cell biology2020
Planar cell polarity signaling in the development of left-right asymmetry.
Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Successful oocyte transport through the oviduct does not depend on the longitudinal alignment of oviduct epithelial folds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Review
- Exposure to Pyriproxyfen Impacts Heart Development Causing Tissue and Cellular Impairments, Heart Arrhythmia and Reduced Embryonic Growth.Cardiovascular toxicology · 2025Article
- Breaking Left-Right Symmetry by the Interplay of Planar Cell Polarity, Calcium Signaling and Cilia.Cells · 2024Review
- Emerging roles and biomarker potential of WNT6 in human cancers.Cell communication and signaling : CCS · 2024Review
- Emergence of planar cell polarity from the interplay of local interactions and global gradients.eLife · 2024Article
- Canonical and Non-Canonical Wnt Signaling Generates Molecular and Cellular Asymmetries to Establish Embryonic Axes.Journal of developmental biology · 2024Review
- Helical vasculogenesis driven by cell chirality.Science advances · 2024Article
- Human Genetics of d-Transposition of Great Arteries.Advances in experimental medicine and biology · 2024Review
- A Van Gogh/Vangl tyrosine phosphorylation switch regulates its interaction with core Planar Cell Polarity factors Prickle and Dishevelled.PLoS genetics · 2023Article
- Methylmercury Toxicity During Heart Development: A Combined Analysis of Morphological and Functional Parameters.Cardiovascular toxicology · 2022Article
- Coordination of Cilia Movements in Multi-Ciliated Cells.Journal of developmental biology · 2022Review
- The genetic landscape of cardiovascular left-right patterning defects.Current opinion in genetics & development · 2022Review
- Cell cycle expression of polarity genes features Rb targeting of Vang.Cells & development · 2022Article
- Is Transposition of the Great Arteries Associated With Shortening of the Intrapericardial Portions of the Great Arterial Trunks? An Echocardiographic Analysis on Newborn Infants With Simple Transposition of the Great Arteries to Explore an Animal Model-Based Hypothesis on Human Beings.Journal of the American Heart Association · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The planar cell polarity (PCP) signaling pathway, principally understood from work in Drosophila, is now known to contribute to development in a broad swath of the animal kingdom, and its impairment leads to developmental malformations and diseases affecting humans. The 'core' mechanism underlying PCP signaling polarizes sheets of cells, aligning them in a head-to-tail fashion within the sheet. Cells use the resulting directional information to guide a wide variety of processes. One such process is lateralization, the determination of left-right asymmetry that guides the asymmetric morphology and placement of internal organs. Recent evidence extends the idea that PCP signaling underlies the earliest steps in lateralization and that PCP is invoked again during asymmetric morphogenesis of organs including the heart and gut.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.